System on a chip for automated cell assays using a lab-on-CMOS platform

Bathiya Senevirathna; Sheung Lu; Nathan Renegar; Marc Dandin; Elisabeth Smela; Pamela Abshire

doi:10.1109/ISCAS.2019.8702702

System on a chip for automated cell assays using a lab-on-CMOS platform

Bathiya Senevirathna
, Sheung Lu
, Nathan Renegar
, Marc Dandin
, Elisabeth Smela
, Pamela Abshire

Electrical Engineering

University of Maryland, College Park
Kiskeya Microsystems

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

We describe a capacitance sensor system-on-chip that has been incorporated into a lab-on-CMOS system for applications in monitoring cell viability. This paper presents system-level improvements to a capacitance sensor array that include programmable gain, active pixel settings, and serial bus addresses, while at the same time minimizing external bonding requirements towards developing a point-of-care device. Results from benchtop experiments are presented using dry flour to mimic for cell coverage, and show a change of up to 35 kHz. Estimation of electrode coverage is obtained using concurrent time-lapse imaging of the sensor surface which is then correlated to the sensor readings.

Original language	English
Title of host publication	2019 IEEE International Symposium on Circuits and Systems, ISCAS 2019 - Proceedings
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781728103976
DOIs	https://doi.org/10.1109/ISCAS.2019.8702702
State	Published - 2019
Event	2019 IEEE International Symposium on Circuits and Systems, ISCAS 2019 - Sapporo, Japan Duration: May 26 2019 → May 29 2019

Publication series

Name	Proceedings - IEEE International Symposium on Circuits and Systems
Volume	2019-May
ISSN (Print)	0271-4310

Conference

Conference	2019 IEEE International Symposium on Circuits and Systems, ISCAS 2019
Country/Territory	Japan
City	Sapporo
Period	05/26/19 → 05/29/19

Keywords

Biosensor chip
Lab on a chip
Point-of-care device
System on chip

Access to Document

10.1109/ISCAS.2019.8702702

Cite this

Senevirathna, B., Lu, S., Renegar, N., Dandin, M., Smela, E., & Abshire, P. (2019). System on a chip for automated cell assays using a lab-on-CMOS platform. In 2019 IEEE International Symposium on Circuits and Systems, ISCAS 2019 - Proceedings Article 8702702 (Proceedings - IEEE International Symposium on Circuits and Systems; Vol. 2019-May). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ISCAS.2019.8702702

@inproceedings{ddb5538991a84b8cba1a52c2e13fe33a,

title = "System on a chip for automated cell assays using a lab-on-CMOS platform",

abstract = " We describe a capacitance sensor system-on-chip that has been incorporated into a lab-on-CMOS system for applications in monitoring cell viability. This paper presents system-level improvements to a capacitance sensor array that include programmable gain, active pixel settings, and serial bus addresses, while at the same time minimizing external bonding requirements towards developing a point-of-care device. Results from benchtop experiments are presented using dry flour to mimic for cell coverage, and show a change of up to 35 kHz. Estimation of electrode coverage is obtained using concurrent time-lapse imaging of the sensor surface which is then correlated to the sensor readings.",

keywords = "Biosensor chip, Lab on a chip, Point-of-care device, System on chip",

author = "Bathiya Senevirathna and Sheung Lu and Nathan Renegar and Marc Dandin and Elisabeth Smela and Pamela Abshire",

note = "Publisher Copyright: {\textcopyright} 2019 IEEE; 2019 IEEE International Symposium on Circuits and Systems, ISCAS 2019 ; Conference date: 26-05-2019 Through 29-05-2019",

year = "2019",

doi = "10.1109/ISCAS.2019.8702702",

language = "English",

series = "Proceedings - IEEE International Symposium on Circuits and Systems",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

booktitle = "2019 IEEE International Symposium on Circuits and Systems, ISCAS 2019 - Proceedings",

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Senevirathna, B, Lu, S, Renegar, N, Dandin, M, Smela, E & Abshire, P 2019, System on a chip for automated cell assays using a lab-on-CMOS platform. in 2019 IEEE International Symposium on Circuits and Systems, ISCAS 2019 - Proceedings., 8702702, Proceedings - IEEE International Symposium on Circuits and Systems, vol. 2019-May, Institute of Electrical and Electronics Engineers Inc., 2019 IEEE International Symposium on Circuits and Systems, ISCAS 2019, Sapporo, Japan, 05/26/19. https://doi.org/10.1109/ISCAS.2019.8702702

System on a chip for automated cell assays using a lab-on-CMOS platform. / Senevirathna, Bathiya; Lu, Sheung; Renegar, Nathan et al.
2019 IEEE International Symposium on Circuits and Systems, ISCAS 2019 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2019. 8702702 (Proceedings - IEEE International Symposium on Circuits and Systems; Vol. 2019-May).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - System on a chip for automated cell assays using a lab-on-CMOS platform

AU - Senevirathna, Bathiya

AU - Lu, Sheung

AU - Renegar, Nathan

AU - Dandin, Marc

AU - Smela, Elisabeth

AU - Abshire, Pamela

PY - 2019

Y1 - 2019

N2 - We describe a capacitance sensor system-on-chip that has been incorporated into a lab-on-CMOS system for applications in monitoring cell viability. This paper presents system-level improvements to a capacitance sensor array that include programmable gain, active pixel settings, and serial bus addresses, while at the same time minimizing external bonding requirements towards developing a point-of-care device. Results from benchtop experiments are presented using dry flour to mimic for cell coverage, and show a change of up to 35 kHz. Estimation of electrode coverage is obtained using concurrent time-lapse imaging of the sensor surface which is then correlated to the sensor readings.

AB - We describe a capacitance sensor system-on-chip that has been incorporated into a lab-on-CMOS system for applications in monitoring cell viability. This paper presents system-level improvements to a capacitance sensor array that include programmable gain, active pixel settings, and serial bus addresses, while at the same time minimizing external bonding requirements towards developing a point-of-care device. Results from benchtop experiments are presented using dry flour to mimic for cell coverage, and show a change of up to 35 kHz. Estimation of electrode coverage is obtained using concurrent time-lapse imaging of the sensor surface which is then correlated to the sensor readings.

KW - Biosensor chip

KW - Lab on a chip

KW - Point-of-care device

KW - System on chip

UR - https://www.scopus.com/pages/publications/85066783580

U2 - 10.1109/ISCAS.2019.8702702

DO - 10.1109/ISCAS.2019.8702702

M3 - Conference contribution

AN - SCOPUS:85066783580

T3 - Proceedings - IEEE International Symposium on Circuits and Systems

BT - 2019 IEEE International Symposium on Circuits and Systems, ISCAS 2019 - Proceedings

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 2019 IEEE International Symposium on Circuits and Systems, ISCAS 2019

Y2 - 26 May 2019 through 29 May 2019

ER -

Senevirathna B, Lu S, Renegar N, Dandin M, Smela E, Abshire P. System on a chip for automated cell assays using a lab-on-CMOS platform. In 2019 IEEE International Symposium on Circuits and Systems, ISCAS 2019 - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2019. 8702702. (Proceedings - IEEE International Symposium on Circuits and Systems). doi: 10.1109/ISCAS.2019.8702702

System on a chip for automated cell assays using a lab-on-CMOS platform

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