Tgf-β: Many paths to CD103+ cd8 T cell residency

Zhijuan Qiu; Timothy H. Chu; Brian S. Sheridan

doi:10.3390/cells10050989

Tgf-β: Many paths to CD103⁺ cd8 T cell residency

Zhijuan Qiu
, Timothy H. Chu
, Brian S. Sheridan

Stony Brook University

Research output: Contribution to journal › Review article › peer-review

42 Scopus citations

Abstract

CD8 tissue-resident memory T (T_RM) cells primarily reside in nonlymphoid tissues without recirculating and provide front-line protective immunity against infections and cancers. CD8 T_RM cells can be generally divided into CD69⁺ CD103⁻ T_RM cells (referred to as CD103⁻ T_RM cells) and CD69⁺ CD103⁺ T_RM cells (referred to as CD103⁺ T_RM cells). TGF-β plays a critical role in the development and maintenance of CD103⁺ CD8 T_RM cells. In this review, we summarize the current understanding of tissue-specific activation of TGF-β mediated by integrins and how it contributes to CD103⁺ CD8 T_RM cell development and maintenance. Furthermore, we discuss the underlying mechanisms utilized by TGF-β to regulate the development and maintenance of CD103⁺ CD8 T_RM cells. Overall, this review highlights the importance of TGF-β in regulating this unique subset of memory CD8 T cells that may shed light on improving vaccine design to target this population.

Original language	English
Article number	989
Journal	Cells
Volume	10
Issue number	5
DOIs	https://doi.org/10.3390/cells10050989
State	Published - May 2021

Keywords

CD103
CD8 tissue-resident memory T cells
Integrin
Kruppel-like factor 2
Memory precursor effector T cells
Short-lived effector T cells
TGF-β

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10.3390/cells10050989

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@article{908293033bba4afb99fe3699f2382a65,

title = "Tgf-β: Many paths to CD103+ cd8 T cell residency",

abstract = "CD8 tissue-resident memory T (TRM) cells primarily reside in nonlymphoid tissues without recirculating and provide front-line protective immunity against infections and cancers. CD8 TRM cells can be generally divided into CD69+ CD103− TRM cells (referred to as CD103− TRM cells) and CD69+ CD103+ TRM cells (referred to as CD103+ TRM cells). TGF-β plays a critical role in the development and maintenance of CD103+ CD8 TRM cells. In this review, we summarize the current understanding of tissue-specific activation of TGF-β mediated by integrins and how it contributes to CD103+ CD8 TRM cell development and maintenance. Furthermore, we discuss the underlying mechanisms utilized by TGF-β to regulate the development and maintenance of CD103+ CD8 TRM cells. Overall, this review highlights the importance of TGF-β in regulating this unique subset of memory CD8 T cells that may shed light on improving vaccine design to target this population.",

keywords = "CD103, CD8 tissue-resident memory T cells, Integrin, Kruppel-like factor 2, Memory precursor effector T cells, Short-lived effector T cells, TGF-β",

author = "Zhijuan Qiu and Chu, \{Timothy H.\} and Sheridan, \{Brian S.\}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = may,

doi = "10.3390/cells10050989",

language = "English",

volume = "10",

journal = "Cells",

issn = "2073-4409",

number = "5",

}

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T1 - Tgf-β

T2 - Many paths to CD103+ cd8 T cell residency

AU - Qiu, Zhijuan

AU - Chu, Timothy H.

AU - Sheridan, Brian S.

PY - 2021/5

Y1 - 2021/5

N2 - CD8 tissue-resident memory T (TRM) cells primarily reside in nonlymphoid tissues without recirculating and provide front-line protective immunity against infections and cancers. CD8 TRM cells can be generally divided into CD69+ CD103− TRM cells (referred to as CD103− TRM cells) and CD69+ CD103+ TRM cells (referred to as CD103+ TRM cells). TGF-β plays a critical role in the development and maintenance of CD103+ CD8 TRM cells. In this review, we summarize the current understanding of tissue-specific activation of TGF-β mediated by integrins and how it contributes to CD103+ CD8 TRM cell development and maintenance. Furthermore, we discuss the underlying mechanisms utilized by TGF-β to regulate the development and maintenance of CD103+ CD8 TRM cells. Overall, this review highlights the importance of TGF-β in regulating this unique subset of memory CD8 T cells that may shed light on improving vaccine design to target this population.

AB - CD8 tissue-resident memory T (TRM) cells primarily reside in nonlymphoid tissues without recirculating and provide front-line protective immunity against infections and cancers. CD8 TRM cells can be generally divided into CD69+ CD103− TRM cells (referred to as CD103− TRM cells) and CD69+ CD103+ TRM cells (referred to as CD103+ TRM cells). TGF-β plays a critical role in the development and maintenance of CD103+ CD8 TRM cells. In this review, we summarize the current understanding of tissue-specific activation of TGF-β mediated by integrins and how it contributes to CD103+ CD8 TRM cell development and maintenance. Furthermore, we discuss the underlying mechanisms utilized by TGF-β to regulate the development and maintenance of CD103+ CD8 TRM cells. Overall, this review highlights the importance of TGF-β in regulating this unique subset of memory CD8 T cells that may shed light on improving vaccine design to target this population.

KW - CD103

KW - CD8 tissue-resident memory T cells

KW - Integrin

KW - Kruppel-like factor 2

KW - Memory precursor effector T cells

KW - Short-lived effector T cells

KW - TGF-β

UR - https://www.scopus.com/pages/publications/85105197575

U2 - 10.3390/cells10050989

DO - 10.3390/cells10050989

M3 - Review article

C2 - 33922441

AN - SCOPUS:85105197575

SN - 2073-4409

VL - 10

JO - Cells

JF - Cells

IS - 5

M1 - 989

ER -

Tgf-β: Many paths to CD103⁺ cd8 T cell residency

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Keywords

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