TY - JOUR
T1 - The association between diabetes and gastric cancer
T2 - results from the Stomach Cancer Pooling Project Consortium
AU - Dabo, Bashir
AU - Pelucchi, Claudio
AU - Rota, Matteo
AU - Jain, Harshonnati
AU - Bertuccio, Paola
AU - Bonzi, Rossella
AU - Palli, Domenico
AU - Ferraroni, Monica
AU - Zhang, Zuo Feng
AU - Sanchez-Anguiano, Aurora
AU - Thi-Hai Pham, Yen
AU - Thi-Du Tran, Chi
AU - Gia Pham, Anh
AU - Yu, Guo Pei
AU - Nguyen, Tin C.
AU - Muscat, Joshua
AU - Tsugane, Shoichiro
AU - Hidaka, Akihisa
AU - Hamada, Gerson S.
AU - Zaridze, David
AU - Maximovitch, Dmitry
AU - Kogevinas, Manolis
AU - Fernàndez De Larrea, Nerea
AU - Boccia, Stefania
AU - Pastorino, Roberta
AU - Kurtz, Robert C.
AU - Lagiou, Areti
AU - Lagiou, Pagona
AU - Vioque, Jesus
AU - Camargo, M. Constanza
AU - Paula Curado, Maria
AU - Lunet, Nuno
AU - Boffetta, Paolo
AU - Negri, Eva
AU - La Vecchia, Carlo
AU - Luu, Hung N.
N1 - Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.
PY - 2022/5/1
Y1 - 2022/5/1
N2 - Background Prior epidemiologic studies on the association between diabetes and gastric cancer risk provided inconclusive findings, while traditional, aggregate data meta-analyses were characterized by high between-study heterogeneity. Objective To investigate the association between type 2 diabetes and gastric cancer using data from the 'Stomach Cancer Pooling (StoP) Project', an international consortium of more than 30 case-control and nested case-control studies, which is large and provides harmonized definition of participants' characteristics across individual studies. The data have the potential to minimize between-study heterogeneity and provide greater statistical power for subgroup analysis. Methods We included 5592 gastric cancer cases and 12 477 controls from 14 studies from Europe, Asia, North America, and South America in a two-stage individual-participant data meta-analysis. Random-effect models were used to estimate summary odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) by pooling study-specific ORs. Results We did not find an overall association between diabetes and gastric cancer (pooled OR = 1.01, 95% CI, 0.94-1.07). However, the risk of cardia gastric cancer was significantly higher among individuals with type 2 diabetes (OR = 1.16, 95% CI, 1.02-1.33). There was no association between diabetes and gastric cancer risk in strata of Helicobacter pylori infection serostatus, age, sex, BMI, smoking status, alcohol consumption, fruit/vegetable intake, gastric cancer histologic type, and source of controls. Conclusion This study provides additional evidence that diabetes is unrelated to gastric cancer overall but may be associated with excess cardia gastric cancer risk.
AB - Background Prior epidemiologic studies on the association between diabetes and gastric cancer risk provided inconclusive findings, while traditional, aggregate data meta-analyses were characterized by high between-study heterogeneity. Objective To investigate the association between type 2 diabetes and gastric cancer using data from the 'Stomach Cancer Pooling (StoP) Project', an international consortium of more than 30 case-control and nested case-control studies, which is large and provides harmonized definition of participants' characteristics across individual studies. The data have the potential to minimize between-study heterogeneity and provide greater statistical power for subgroup analysis. Methods We included 5592 gastric cancer cases and 12 477 controls from 14 studies from Europe, Asia, North America, and South America in a two-stage individual-participant data meta-analysis. Random-effect models were used to estimate summary odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) by pooling study-specific ORs. Results We did not find an overall association between diabetes and gastric cancer (pooled OR = 1.01, 95% CI, 0.94-1.07). However, the risk of cardia gastric cancer was significantly higher among individuals with type 2 diabetes (OR = 1.16, 95% CI, 1.02-1.33). There was no association between diabetes and gastric cancer risk in strata of Helicobacter pylori infection serostatus, age, sex, BMI, smoking status, alcohol consumption, fruit/vegetable intake, gastric cancer histologic type, and source of controls. Conclusion This study provides additional evidence that diabetes is unrelated to gastric cancer overall but may be associated with excess cardia gastric cancer risk.
KW - diabetes
KW - gastric cancer
KW - risk factors
UR - https://www.scopus.com/pages/publications/85128245161
U2 - 10.1097/CEJ.0000000000000703
DO - 10.1097/CEJ.0000000000000703
M3 - Article
C2 - 34183534
AN - SCOPUS:85128245161
SN - 0959-8278
VL - 31
SP - 260
EP - 269
JO - European Journal of Cancer Prevention
JF - European Journal of Cancer Prevention
IS - 3
ER -