TY - JOUR
T1 - The association between dietary fiber intake and gastric cancer
T2 - a pooled analysis of 11 case–control studies
AU - Collatuzzo, Giulia
AU - Cortez Lainez, Jacqueline
AU - Pelucchi, Claudio
AU - Negri, Eva
AU - Bonzi, Rossella
AU - Palli, Domenico
AU - Ferraroni, Monica
AU - Zhang, Zuo Feng
AU - Yu, Guo Pei
AU - Lunet, Nuno
AU - Morais, Samantha
AU - López-Carrillo, Lizbeth
AU - Zaridze, David
AU - Maximovitch, Dmitry
AU - Guevara, Marcela
AU - Santos-Sanchez, Vanessa
AU - Vioque, Jesus
AU - Garcia de la Hera, Manoli
AU - Ward, Mary H.
AU - Malekzadeh, Reza
AU - Pakseresht, Mohammadreza
AU - Hernández-Ramírez, Raúl Ulises
AU - Turati, Federica
AU - Rabkin, Charles S.
AU - Liao, Linda M.
AU - Sinha, Rashmi
AU - López-Cervantes, Malaquias
AU - Tsugane, Shoichiro
AU - Hidaka, Akihisa
AU - Camargo, M. Constanza
AU - Curado, Maria Paula
AU - Zubair, Nadia
AU - Kristjansson, Dana
AU - Shah, Shailja
AU - La Vecchia, Carlo
AU - Boffetta, Paolo
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/8
Y1 - 2024/8
N2 - Purpose: Gastric cancer (GC) is among the leading causes of cancer mortality worldwide. The objective of this study was to investigate the association between dietary fiber intake and GC. Methods: We pooled data from 11 population or hospital-based case–control studies included in the Stomach Cancer Pooling (StoP) Project, for a total of 4865 histologically confirmed cases and 10,626 controls. Intake of dietary fibers and other dietary factors was collected using food frequency questionnaires. We calculated the odds ratios (OR) and 95% confidence intervals (CI) of the association between dietary fiber intake and GC by using a multivariable logistic regression model adjusted for study site, sex, age, caloric intake, smoking, fruit and vegetable intake, and socioeconomic status. We conducted stratified analyses by these factors, as well as GC anatomical site and histological type. Results: The OR of GC for an increase of one quartile of fiber intake was 0.91 (95% CI: 0.85, 0.97), that for the highest compared to the lowest quartile of dietary fiber intake was 0.72 (95% CI: 0.59, 0.88). Results were similar irrespective of anatomical site and histological type. Conclusion: Our analysis supports the hypothesis that dietary fiber intake may exert a protective effect on GC.
AB - Purpose: Gastric cancer (GC) is among the leading causes of cancer mortality worldwide. The objective of this study was to investigate the association between dietary fiber intake and GC. Methods: We pooled data from 11 population or hospital-based case–control studies included in the Stomach Cancer Pooling (StoP) Project, for a total of 4865 histologically confirmed cases and 10,626 controls. Intake of dietary fibers and other dietary factors was collected using food frequency questionnaires. We calculated the odds ratios (OR) and 95% confidence intervals (CI) of the association between dietary fiber intake and GC by using a multivariable logistic regression model adjusted for study site, sex, age, caloric intake, smoking, fruit and vegetable intake, and socioeconomic status. We conducted stratified analyses by these factors, as well as GC anatomical site and histological type. Results: The OR of GC for an increase of one quartile of fiber intake was 0.91 (95% CI: 0.85, 0.97), that for the highest compared to the lowest quartile of dietary fiber intake was 0.72 (95% CI: 0.59, 0.88). Results were similar irrespective of anatomical site and histological type. Conclusion: Our analysis supports the hypothesis that dietary fiber intake may exert a protective effect on GC.
KW - Cardia
KW - Dietary fiber
KW - Fiber intake
KW - Gastric cancer
KW - Gastric neoplasm
KW - Non-cardia
UR - https://www.scopus.com/pages/publications/85191790295
U2 - 10.1007/s00394-024-03388-w
DO - 10.1007/s00394-024-03388-w
M3 - Article
C2 - 38687390
AN - SCOPUS:85191790295
SN - 1436-6207
VL - 63
SP - 1857
EP - 1865
JO - European Journal of Nutrition
JF - European Journal of Nutrition
IS - 5
ER -