The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium

Pedram Paragomi; Bashir Dabo; Claudio Pelucchi; Rossella Bonzi; Abdulaziz T. Bako; Nabila Muhammad Sanusi; Quan H. Nguyen; Zuo Feng Zhang; Domenico Palli; Monica Ferraroni; Khanh Truong Vu; Guo Pei Yu; Federica Turati; David Zaridze; Dmitry Maximovitch; Jinfu Hu; Lina Mu; Stefania Boccia; Roberta Pastorino; Shoichiro Tsugane; Akihisa Hidaka; Robert C. Kurtz; Areti Lagiou; Pagona Lagiou; M. Constanza Camargo; Maria Paula Curado; Nuno Lunet; Jesus Vioque; Paolo Boffetta; Eva Negri; Carlo La Vecchia; Hung N. Luu

doi:10.3390/cancers14194905

The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium

Pedram Paragomi
, Bashir Dabo
, Claudio Pelucchi
, Rossella Bonzi
, Abdulaziz T. Bako
, Nabila Muhammad Sanusi
, Quan H. Nguyen
, Zuo Feng Zhang
, Domenico Palli
, Monica Ferraroni
, Khanh Truong Vu
, Guo Pei Yu
, Federica Turati
, David Zaridze
, Dmitry Maximovitch
, Jinfu Hu
, Lina Mu
, Stefania Boccia
, Roberta Pastorino
, Shoichiro Tsugane

Akihisa Hidaka, Robert C. Kurtz, Areti Lagiou, Pagona Lagiou, M. Constanza Camargo, Maria Paula Curado, Nuno Lunet, Jesus Vioque, Paolo Boffetta, Eva Negri, Carlo La Vecchia, Hung N. Luu

Family , Population and Preventative Medicine

University of Pittsburgh
University of South Florida
Bayero University
University of Milan
Houston Methodist
University of Queensland
University of California at Los Angeles
Institute for the Study and Prevention of Cancer
Tam Anh General Hospital
Peking University
Blokhin Cancer Research Center
Harbin Medical University
SUNY Buffalo
Catholic University of the Sacred Heart
Fondazione Policlinico Universitario A.Gemelli IRCS
National Cancer Center Japan
National Institutes of Biomedical Innovation, Health and Nutrition
Memorial Sloan-Kettering Cancer Center
University of West Attica
National and Kapodistrian University of Athens
Harvard University
National Institutes of Health
A.C.Camargo Cancer Center
University of Porto
Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR)
Miguel Hernández University
CIBER Epidemiología y Salud Pública (CIBERESP)
University of Bologna

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Background. Gastric cancer (GC) is the fifth most common type of cancer and the fourth most common cause of cancer-related mortality. Although the risk of GC and peptic ulcer disease (PUD) is known to be increased by H. pylori infection, evidence regarding the direct relationship between PUD and GC across ethnicities is inconclusive. Therefore, we investigated the association between PUD and GC in the Stomach cancer Pooling (StoP) consortium. Methods. History of peptic ulcer disease was collected using a structured questionnaire in 11 studies in the StoP consortium, including 4106 GC cases and 6922 controls. The two-stage individual-participant data meta-analysis approach was adopted to generate a priori. Unconditional logistic regression and Firth’s penalized maximum likelihood estimator were used to calculate study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between gastric ulcer (GU)/duodenal ulcer (DU) and risk of GC. Results. History of GU and DU was thoroughly reported and used in association analysis, respectively, by 487 cases (12.5%) and 276 controls (4.1%), and 253 cases (7.8%) and 318 controls (6.0%). We found that GU was associated with an increased risk of GC (OR = 3.04, 95% CI: 2.07–4.49). No association between DU and GC risk was observed (OR = 1.03, 95% CI: 0.77–1.39). Conclusions. In the pooled analysis of 11 case–control studies in a large consortium (i.e., the Stomach cancer Pooling (StoP) consortium), we found a positive association between GU and risk of GC and no association between DU and GC risk.

Original language	English
Article number	4905
Journal	Cancers
Volume	14
Issue number	19
DOIs	https://doi.org/10.3390/cancers14194905
State	Published - Oct 2022

Keywords

duodenal ulcers (DUs)
gastric cancer
Gastric ulcers (Gus)
risk factors

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10.3390/cancers14194905

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Paragomi, P., Dabo, B., Pelucchi, C., Bonzi, R., Bako, A. T., Sanusi, N. M., Nguyen, Q. H., Zhang, Z. F., Palli, D., Ferraroni, M., Vu, K. T., Yu, G. P., Turati, F., Zaridze, D., Maximovitch, D., Hu, J., Mu, L., Boccia, S., Pastorino, R., ... Luu, H. N. (2022). The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium. Cancers, 14(19), Article 4905. https://doi.org/10.3390/cancers14194905

@article{56052bdd6ae94ed1946cab7840d3b118,

title = "The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium",

abstract = "Background. Gastric cancer (GC) is the fifth most common type of cancer and the fourth most common cause of cancer-related mortality. Although the risk of GC and peptic ulcer disease (PUD) is known to be increased by H. pylori infection, evidence regarding the direct relationship between PUD and GC across ethnicities is inconclusive. Therefore, we investigated the association between PUD and GC in the Stomach cancer Pooling (StoP) consortium. Methods. History of peptic ulcer disease was collected using a structured questionnaire in 11 studies in the StoP consortium, including 4106 GC cases and 6922 controls. The two-stage individual-participant data meta-analysis approach was adopted to generate a priori. Unconditional logistic regression and Firth{\textquoteright}s penalized maximum likelihood estimator were used to calculate study-specific odds ratios (ORs) and 95\% confidence intervals (CIs) for the association between gastric ulcer (GU)/duodenal ulcer (DU) and risk of GC. Results. History of GU and DU was thoroughly reported and used in association analysis, respectively, by 487 cases (12.5\%) and 276 controls (4.1\%), and 253 cases (7.8\%) and 318 controls (6.0\%). We found that GU was associated with an increased risk of GC (OR = 3.04, 95\% CI: 2.07{\textendash}4.49). No association between DU and GC risk was observed (OR = 1.03, 95\% CI: 0.77{\textendash}1.39). Conclusions. In the pooled analysis of 11 case{\textendash}control studies in a large consortium (i.e., the Stomach cancer Pooling (StoP) consortium), we found a positive association between GU and risk of GC and no association between DU and GC risk.",

keywords = "duodenal ulcers (DUs), gastric cancer, Gastric ulcers (Gus), risk factors",

author = "Pedram Paragomi and Bashir Dabo and Claudio Pelucchi and Rossella Bonzi and Bako, \{Abdulaziz T.\} and Sanusi, \{Nabila Muhammad\} and Nguyen, \{Quan H.\} and Zhang, \{Zuo Feng\} and Domenico Palli and Monica Ferraroni and Vu, \{Khanh Truong\} and Yu, \{Guo Pei\} and Federica Turati and David Zaridze and Dmitry Maximovitch and Jinfu Hu and Lina Mu and Stefania Boccia and Roberta Pastorino and Shoichiro Tsugane and Akihisa Hidaka and Kurtz, \{Robert C.\} and Areti Lagiou and Pagona Lagiou and Camargo, \{M. Constanza\} and Curado, \{Maria Paula\} and Nuno Lunet and Jesus Vioque and Paolo Boffetta and Eva Negri and \{La Vecchia\}, Carlo and Luu, \{Hung N.\}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = oct,

doi = "10.3390/cancers14194905",

language = "English",

volume = "14",

journal = "Cancers",

issn = "2072-6694",

number = "19",

}

Paragomi, P, Dabo, B, Pelucchi, C, Bonzi, R, Bako, AT, Sanusi, NM, Nguyen, QH, Zhang, ZF, Palli, D, Ferraroni, M, Vu, KT, Yu, GP, Turati, F, Zaridze, D, Maximovitch, D, Hu, J, Mu, L, Boccia, S, Pastorino, R, Tsugane, S, Hidaka, A, Kurtz, RC, Lagiou, A, Lagiou, P, Camargo, MC, Curado, MP, Lunet, N, Vioque, J, Boffetta, P, Negri, E, La Vecchia, C & Luu, HN 2022, 'The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium', Cancers, vol. 14, no. 19, 4905. https://doi.org/10.3390/cancers14194905

TY - JOUR

T1 - The Association between Peptic Ulcer Disease and Gastric Cancer

T2 - Results from the Stomach Cancer Pooling (StoP) Project Consortium

AU - Paragomi, Pedram

AU - Dabo, Bashir

AU - Pelucchi, Claudio

AU - Bonzi, Rossella

AU - Bako, Abdulaziz T.

AU - Sanusi, Nabila Muhammad

AU - Nguyen, Quan H.

AU - Zhang, Zuo Feng

AU - Palli, Domenico

AU - Ferraroni, Monica

AU - Vu, Khanh Truong

AU - Yu, Guo Pei

AU - Turati, Federica

AU - Zaridze, David

AU - Maximovitch, Dmitry

AU - Hu, Jinfu

AU - Mu, Lina

AU - Boccia, Stefania

AU - Pastorino, Roberta

AU - Tsugane, Shoichiro

AU - Hidaka, Akihisa

AU - Kurtz, Robert C.

AU - Lagiou, Areti

AU - Lagiou, Pagona

AU - Camargo, M. Constanza

AU - Curado, Maria Paula

AU - Lunet, Nuno

AU - Vioque, Jesus

AU - Boffetta, Paolo

AU - Negri, Eva

AU - La Vecchia, Carlo

AU - Luu, Hung N.

PY - 2022/10

Y1 - 2022/10

N2 - Background. Gastric cancer (GC) is the fifth most common type of cancer and the fourth most common cause of cancer-related mortality. Although the risk of GC and peptic ulcer disease (PUD) is known to be increased by H. pylori infection, evidence regarding the direct relationship between PUD and GC across ethnicities is inconclusive. Therefore, we investigated the association between PUD and GC in the Stomach cancer Pooling (StoP) consortium. Methods. History of peptic ulcer disease was collected using a structured questionnaire in 11 studies in the StoP consortium, including 4106 GC cases and 6922 controls. The two-stage individual-participant data meta-analysis approach was adopted to generate a priori. Unconditional logistic regression and Firth’s penalized maximum likelihood estimator were used to calculate study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between gastric ulcer (GU)/duodenal ulcer (DU) and risk of GC. Results. History of GU and DU was thoroughly reported and used in association analysis, respectively, by 487 cases (12.5%) and 276 controls (4.1%), and 253 cases (7.8%) and 318 controls (6.0%). We found that GU was associated with an increased risk of GC (OR = 3.04, 95% CI: 2.07–4.49). No association between DU and GC risk was observed (OR = 1.03, 95% CI: 0.77–1.39). Conclusions. In the pooled analysis of 11 case–control studies in a large consortium (i.e., the Stomach cancer Pooling (StoP) consortium), we found a positive association between GU and risk of GC and no association between DU and GC risk.

AB - Background. Gastric cancer (GC) is the fifth most common type of cancer and the fourth most common cause of cancer-related mortality. Although the risk of GC and peptic ulcer disease (PUD) is known to be increased by H. pylori infection, evidence regarding the direct relationship between PUD and GC across ethnicities is inconclusive. Therefore, we investigated the association between PUD and GC in the Stomach cancer Pooling (StoP) consortium. Methods. History of peptic ulcer disease was collected using a structured questionnaire in 11 studies in the StoP consortium, including 4106 GC cases and 6922 controls. The two-stage individual-participant data meta-analysis approach was adopted to generate a priori. Unconditional logistic regression and Firth’s penalized maximum likelihood estimator were used to calculate study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between gastric ulcer (GU)/duodenal ulcer (DU) and risk of GC. Results. History of GU and DU was thoroughly reported and used in association analysis, respectively, by 487 cases (12.5%) and 276 controls (4.1%), and 253 cases (7.8%) and 318 controls (6.0%). We found that GU was associated with an increased risk of GC (OR = 3.04, 95% CI: 2.07–4.49). No association between DU and GC risk was observed (OR = 1.03, 95% CI: 0.77–1.39). Conclusions. In the pooled analysis of 11 case–control studies in a large consortium (i.e., the Stomach cancer Pooling (StoP) consortium), we found a positive association between GU and risk of GC and no association between DU and GC risk.

KW - duodenal ulcers (DUs)

KW - gastric cancer

KW - Gastric ulcers (Gus)

KW - risk factors

UR - https://www.scopus.com/pages/publications/85139842258

U2 - 10.3390/cancers14194905

DO - 10.3390/cancers14194905

M3 - Article

AN - SCOPUS:85139842258

SN - 2072-6694

VL - 14

JO - Cancers

JF - Cancers

IS - 19

M1 - 4905

ER -

The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium

Abstract

Keywords

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