TY - GEN
T1 - The effect of dynamic muscle stimulation on the musculo-skeletal remodeling
AU - Lam, H.
AU - Qin, Y. X.
PY - 2007
Y1 - 2007
N2 - Elucidation of the interactive mechanism between musculoskeletal circulations and bone remodeling is crucial in developing new intervention to prevent bone loss under a microgravity environment. The overall hypothesis is that dynamic muscle stimulation can enhance fluid circulation in bone, regulate osteogenic adaptation, and inhibit bone loss in a functional disuse condition. Using a hindlimb suspension rat model, electro-induced dynamic muscle contraction was induced as replacement of the normal weight-bearing activity of the hindlimb. Dynamic muscle contraction loading at 20Hz and 50Hz demonstrated increase of BV/TV, Conn.D, and Tb.N at the metaphyseal regions, when comparing to the hindlimb suspension control. In addition, stimulation at 20Hz and 50Hz can also alleviate the reduction of the cross-sectional fiber area. These results demonstrated that dynamic electro-induced muscle contraction can indeed initiate an adaptive response to inhibit bone loss and reduce muscle atrophy under a functional disuse environment.
AB - Elucidation of the interactive mechanism between musculoskeletal circulations and bone remodeling is crucial in developing new intervention to prevent bone loss under a microgravity environment. The overall hypothesis is that dynamic muscle stimulation can enhance fluid circulation in bone, regulate osteogenic adaptation, and inhibit bone loss in a functional disuse condition. Using a hindlimb suspension rat model, electro-induced dynamic muscle contraction was induced as replacement of the normal weight-bearing activity of the hindlimb. Dynamic muscle contraction loading at 20Hz and 50Hz demonstrated increase of BV/TV, Conn.D, and Tb.N at the metaphyseal regions, when comparing to the hindlimb suspension control. In addition, stimulation at 20Hz and 50Hz can also alleviate the reduction of the cross-sectional fiber area. These results demonstrated that dynamic electro-induced muscle contraction can indeed initiate an adaptive response to inhibit bone loss and reduce muscle atrophy under a functional disuse environment.
UR - https://www.scopus.com/pages/publications/48749126504
U2 - 10.1109/NEBC.2007.4413263
DO - 10.1109/NEBC.2007.4413263
M3 - Conference contribution
AN - SCOPUS:48749126504
SN - 1424410339
SN - 9781424410330
T3 - Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
SP - 27
EP - 28
BT - 33rd Annual Northeast Bioengineering Conference - Engineering Innovations in Life Sciences and Healthcare, NEBC
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 33rd Annual Northeast Bioengineering Conference, NEBC
Y2 - 10 March 2007 through 11 March 2007
ER -