The effect of ethanol on the expression of HLA class I genes in human colon adenocarcinoma cell lines

Efstathios D. Papavassiliou; Padma Arvind; George J. Tsioulias; Liang Qiao; Edward Goldin; Lisa Staiano-Coico; Basil Rigas

doi:10.1016/0304-3835(94)90161-9

The effect of ethanol on the expression of HLA class I genes in human colon adenocarcinoma cell lines

Efstathios D. Papavassiliou
, Padma Arvind
, George J. Tsioulias
, Liang Qiao
, Edward Goldin
, Lisa Staiano-Coico
, Basil Rigas

Family , Population and Preventative Medicine

Cornell University

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The loss of HLA antigens by neoplastic cells may allow tumors to escape immune surveillance. We observed reduced expression of HLA antigens during human colon carcinogenesis. Since ethanol, which is associated with human colonic carcinogenesis, modulates the expression of HLA genes, we examined whether it affects the expression of HLA class I genes in human colon adenocarcinoma cell lines. Ethanol (1.7 × 10^-10 M to 1.7 × 10^-1 M), had no effect on the expression of HLA class I antigens on these colonocytes, the corresponding mRNA levels, or the expression of HLA constructs. Our findings do not support the hypothesis that ethanol may modulate the expression of HLA class I genes in human colon cancer cells.

Original language	English
Pages (from-to)	33-38
Number of pages	6
Journal	Cancer Letters
Volume	81
Issue number	1
DOIs	https://doi.org/10.1016/0304-3835(94)90161-9
State	Published - Jun 15 1994

Keywords

Carcinogenesis
Colon cancer
Ethanol
Gene regulation
HLA

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10.1016/0304-3835(94)90161-9

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title = "The effect of ethanol on the expression of HLA class I genes in human colon adenocarcinoma cell lines",

abstract = "The loss of HLA antigens by neoplastic cells may allow tumors to escape immune surveillance. We observed reduced expression of HLA antigens during human colon carcinogenesis. Since ethanol, which is associated with human colonic carcinogenesis, modulates the expression of HLA genes, we examined whether it affects the expression of HLA class I genes in human colon adenocarcinoma cell lines. Ethanol (1.7 × 10-10 M to 1.7 × 10-1 M), had no effect on the expression of HLA class I antigens on these colonocytes, the corresponding mRNA levels, or the expression of HLA constructs. Our findings do not support the hypothesis that ethanol may modulate the expression of HLA class I genes in human colon cancer cells.",

keywords = "Carcinogenesis, Colon cancer, Ethanol, Gene regulation, HLA",

author = "Papavassiliou, \{Efstathios D.\} and Padma Arvind and Tsioulias, \{George J.\} and Liang Qiao and Edward Goldin and Lisa Staiano-Coico and Basil Rigas",

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T1 - The effect of ethanol on the expression of HLA class I genes in human colon adenocarcinoma cell lines

AU - Papavassiliou, Efstathios D.

AU - Arvind, Padma

AU - Tsioulias, George J.

AU - Qiao, Liang

AU - Goldin, Edward

AU - Staiano-Coico, Lisa

AU - Rigas, Basil

PY - 1994/6/15

Y1 - 1994/6/15

N2 - The loss of HLA antigens by neoplastic cells may allow tumors to escape immune surveillance. We observed reduced expression of HLA antigens during human colon carcinogenesis. Since ethanol, which is associated with human colonic carcinogenesis, modulates the expression of HLA genes, we examined whether it affects the expression of HLA class I genes in human colon adenocarcinoma cell lines. Ethanol (1.7 × 10-10 M to 1.7 × 10-1 M), had no effect on the expression of HLA class I antigens on these colonocytes, the corresponding mRNA levels, or the expression of HLA constructs. Our findings do not support the hypothesis that ethanol may modulate the expression of HLA class I genes in human colon cancer cells.

AB - The loss of HLA antigens by neoplastic cells may allow tumors to escape immune surveillance. We observed reduced expression of HLA antigens during human colon carcinogenesis. Since ethanol, which is associated with human colonic carcinogenesis, modulates the expression of HLA genes, we examined whether it affects the expression of HLA class I genes in human colon adenocarcinoma cell lines. Ethanol (1.7 × 10-10 M to 1.7 × 10-1 M), had no effect on the expression of HLA class I antigens on these colonocytes, the corresponding mRNA levels, or the expression of HLA constructs. Our findings do not support the hypothesis that ethanol may modulate the expression of HLA class I genes in human colon cancer cells.

KW - Carcinogenesis

KW - Colon cancer

KW - Ethanol

KW - Gene regulation

KW - HLA

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DO - 10.1016/0304-3835(94)90161-9

M3 - Article

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AN - SCOPUS:0028235525

SN - 0304-3835

VL - 81

SP - 33

EP - 38

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

The effect of ethanol on the expression of HLA class I genes in human colon adenocarcinoma cell lines

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