The Effect of Sperm DNA Fragmentation on Male Fertility and Strategies for Improvement: A Narrative Review

Justin Loloi; Francis Petrella; Eliyahu Kresch; Emad Ibrahim; Armand Zini; Ranjith Ramasamy

doi:10.1016/j.urology.2022.05.036

The Effect of Sperm DNA Fragmentation on Male Fertility and Strategies for Improvement: A Narrative Review

Justin Loloi
, Francis Petrella
, Eliyahu Kresch
, Emad Ibrahim
, Armand Zini
, Ranjith Ramasamy

Urology

McGill University
University of Miami

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

The inability to conceive due to male infertility is a complex issue with a wide variety of etiologies. Sperm DNA damage can be both a barrier to natural pregnancy and successful assisted reproductive technology (ART). The aim of this narrative review was to describe and highlight the effects of sperm DNA fragmentation and the most recent data on various treatment strategies to decrease sperm DNA damage. Finally, we proposed a management algorithm for couples undergoing ART with increased sperm DNA fragmentation.

Original language	English
Pages (from-to)	3-9
Number of pages	7
Journal	Urology
Volume	168
DOIs	https://doi.org/10.1016/j.urology.2022.05.036
State	Published - Oct 2022

Access to Document

10.1016/j.urology.2022.05.036

Cite this

@article{38971e8616d4428cace6aa0231480395,

title = "The Effect of Sperm DNA Fragmentation on Male Fertility and Strategies for Improvement: A Narrative Review",

abstract = "The inability to conceive due to male infertility is a complex issue with a wide variety of etiologies. Sperm DNA damage can be both a barrier to natural pregnancy and successful assisted reproductive technology (ART). The aim of this narrative review was to describe and highlight the effects of sperm DNA fragmentation and the most recent data on various treatment strategies to decrease sperm DNA damage. Finally, we proposed a management algorithm for couples undergoing ART with increased sperm DNA fragmentation.",

author = "Justin Loloi and Francis Petrella and Eliyahu Kresch and Emad Ibrahim and Armand Zini and Ranjith Ramasamy",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

month = oct,

doi = "10.1016/j.urology.2022.05.036",

language = "English",

volume = "168",

pages = "3--9",

journal = "Urology",

issn = "0090-4295",

}

TY - JOUR

T1 - The Effect of Sperm DNA Fragmentation on Male Fertility and Strategies for Improvement

T2 - A Narrative Review

AU - Loloi, Justin

AU - Petrella, Francis

AU - Kresch, Eliyahu

AU - Ibrahim, Emad

AU - Zini, Armand

AU - Ramasamy, Ranjith

PY - 2022/10

Y1 - 2022/10

N2 - The inability to conceive due to male infertility is a complex issue with a wide variety of etiologies. Sperm DNA damage can be both a barrier to natural pregnancy and successful assisted reproductive technology (ART). The aim of this narrative review was to describe and highlight the effects of sperm DNA fragmentation and the most recent data on various treatment strategies to decrease sperm DNA damage. Finally, we proposed a management algorithm for couples undergoing ART with increased sperm DNA fragmentation.

AB - The inability to conceive due to male infertility is a complex issue with a wide variety of etiologies. Sperm DNA damage can be both a barrier to natural pregnancy and successful assisted reproductive technology (ART). The aim of this narrative review was to describe and highlight the effects of sperm DNA fragmentation and the most recent data on various treatment strategies to decrease sperm DNA damage. Finally, we proposed a management algorithm for couples undergoing ART with increased sperm DNA fragmentation.

UR - https://www.scopus.com/pages/publications/85133750919

U2 - 10.1016/j.urology.2022.05.036

DO - 10.1016/j.urology.2022.05.036

M3 - Review article

C2 - 35705123

AN - SCOPUS:85133750919

SN - 0090-4295

VL - 168

SP - 3

EP - 9

JO - Urology

JF - Urology

ER -

The Effect of Sperm DNA Fragmentation on Male Fertility and Strategies for Improvement: A Narrative Review

Abstract

Access to Document

Other files and links

Fingerprint

Cite this