The pathobiology of Dupuytren's contracture: Effects of prostaglandins on myofibroblasts

Lawrence C. Hurst; Marie A. Badalamente; Jill Makowski

doi:10.1016/S0363-5023(86)80093-4

The pathobiology of Dupuytren's contracture: Effects of prostaglandins on myofibroblasts

Orthopaedics

Stony Brook University

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23 Scopus citations

Abstract

The in vitro response of myofibroblasts to prostaglandins F_2Î±, (a vasoconstrictor) and E₂ (a vasodilator) were evaluated in specimens obtained from the Dupuytren's nodules of 12 patients. Fibroblasts from four control samples of palmar fascia were similarly tested. This study demonstrated the ability of prostaglandin F_2Î± to induce significant contraction of myofibroblasts. Prostaglandin E₂ was noted to cause significant relaxation of myofibroblasts. The contractile/ relaxation responses of control fibroblasts to these prostaglandins were minimal.

Original language	English
Pages (from-to)	18-23
Number of pages	6
Journal	Journal of Hand Surgery
Volume	11
Issue number	1
DOIs	https://doi.org/10.1016/S0363-5023(86)80093-4
State	Published - 1986

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title = "The pathobiology of Dupuytren's contracture: Effects of prostaglandins on myofibroblasts",

abstract = "The in vitro response of myofibroblasts to prostaglandins F2{\^I}±, (a vasoconstrictor) and E2 (a vasodilator) were evaluated in specimens obtained from the Dupuytren's nodules of 12 patients. Fibroblasts from four control samples of palmar fascia were similarly tested. This study demonstrated the ability of prostaglandin F2{\^I}± to induce significant contraction of myofibroblasts. Prostaglandin E2 was noted to cause significant relaxation of myofibroblasts. The contractile/ relaxation responses of control fibroblasts to these prostaglandins were minimal.",

author = "Hurst, \{Lawrence C.\} and Badalamente, \{Marie A.\} and Jill Makowski",

year = "1986",

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T2 - Effects of prostaglandins on myofibroblasts

AU - Hurst, Lawrence C.

AU - Badalamente, Marie A.

AU - Makowski, Jill

PY - 1986

Y1 - 1986

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AB - The in vitro response of myofibroblasts to prostaglandins F2Î±, (a vasoconstrictor) and E2 (a vasodilator) were evaluated in specimens obtained from the Dupuytren's nodules of 12 patients. Fibroblasts from four control samples of palmar fascia were similarly tested. This study demonstrated the ability of prostaglandin F2Î± to induce significant contraction of myofibroblasts. Prostaglandin E2 was noted to cause significant relaxation of myofibroblasts. The contractile/ relaxation responses of control fibroblasts to these prostaglandins were minimal.

UR - https://www.scopus.com/pages/publications/0022645823

U2 - 10.1016/S0363-5023(86)80093-4

DO - 10.1016/S0363-5023(86)80093-4

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AN - SCOPUS:0022645823

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SP - 18

EP - 23

JO - Journal of Hand Surgery

JF - Journal of Hand Surgery

IS - 1

ER -

The pathobiology of Dupuytren's contracture: Effects of prostaglandins on myofibroblasts

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