The plasmin inhibitors of human plasma. III. Purification and partial characterization

Y. Shamash; A. Rimon

doi:10.1016/0304-4165(66)90346-1

The plasmin inhibitors of human plasma. III. Purification and partial characterization

Y. Shamash
, A. Rimon

Electrical Engineering

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Purification of plasmin inhibitors of human plasma by ion-exchange chromatography on DEAE-Sephadex and by electrophoresis on starch-gel is described. The purified material was found to be an α₁-globulin, heat and acid labile and containing 8% carbohydrates. A mol. wt. of 55 000 was calculated from a sedimentation constant of 3.3 and a diffusion constant of 5.2. The purified inhibitor exhibited both "slow" and "immediate" antiplasmin activities.

Original language	English
Pages (from-to)	35-41
Number of pages	7
Journal	BBA - General Subjects
Volume	121
Issue number	1
DOIs	https://doi.org/10.1016/0304-4165(66)90346-1
State	Published - May 26 1966

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abstract = "Purification of plasmin inhibitors of human plasma by ion-exchange chromatography on DEAE-Sephadex and by electrophoresis on starch-gel is described. The purified material was found to be an α1-globulin, heat and acid labile and containing 8\% carbohydrates. A mol. wt. of 55 000 was calculated from a sedimentation constant of 3.3 and a diffusion constant of 5.2. The purified inhibitor exhibited both {"}slow{"} and {"}immediate{"} antiplasmin activities.",

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AU - Shamash, Y.

AU - Rimon, A.

PY - 1966/5/26

Y1 - 1966/5/26

N2 - Purification of plasmin inhibitors of human plasma by ion-exchange chromatography on DEAE-Sephadex and by electrophoresis on starch-gel is described. The purified material was found to be an α1-globulin, heat and acid labile and containing 8% carbohydrates. A mol. wt. of 55 000 was calculated from a sedimentation constant of 3.3 and a diffusion constant of 5.2. The purified inhibitor exhibited both "slow" and "immediate" antiplasmin activities.

AB - Purification of plasmin inhibitors of human plasma by ion-exchange chromatography on DEAE-Sephadex and by electrophoresis on starch-gel is described. The purified material was found to be an α1-globulin, heat and acid labile and containing 8% carbohydrates. A mol. wt. of 55 000 was calculated from a sedimentation constant of 3.3 and a diffusion constant of 5.2. The purified inhibitor exhibited both "slow" and "immediate" antiplasmin activities.

UR - https://www.scopus.com/pages/publications/0014028743

U2 - 10.1016/0304-4165(66)90346-1

DO - 10.1016/0304-4165(66)90346-1

M3 - Article

C2 - 4224897

AN - SCOPUS:0014028743

SN - 0304-4165

VL - 121

SP - 35

EP - 41

JO - BBA - General Subjects

JF - BBA - General Subjects

IS - 1

ER -

The plasmin inhibitors of human plasma. III. Purification and partial characterization

Abstract

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