Abstract
Mammalian phospholipase D (PLD), a signal transduction-activated enzyme, hydrolyzes phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline. Genetic and pharmacological methods have implicated PLD and its product PA in a wide variety of cellular processes including vesicle trafficking, receptor signaling, cell proliferation and survival. Dysregulation of these cell biologic processes occurs in a diverse range of illnesses including cancer. This review summarizes PLD regulation and function and highlights its potential as a therapeutic target in disease settings.
| Original language | English |
|---|---|
| Pages (from-to) | 707-716 |
| Number of pages | 10 |
| Journal | Expert Opinion on Therapeutic Targets |
| Volume | 11 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2007 |
Keywords
- Cell survival
- Phosphatidic acid
- Phospholipase D
- Vesicle trafficking
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