The roles of neutral sphingomyelinases in neurological pathologies

Charles R. Horres; Yusuf A. Hannun

doi:10.1007/s11064-011-0692-y

The roles of neutral sphingomyelinases in neurological pathologies

Charles R. Horres
, Yusuf A. Hannun

Cancer Center

Medical University of South Carolina

Research output: Contribution to journal › Review article › peer-review

52 Scopus citations

Abstract

The neutral sphingomyelinases (N-SMases) are a group of Mg ²⁺-dependent enzymes with a pH optimum in the neutral range. N-SMases catalyze the conversion of sphingomyelin to ceramide and have been found particularly enriched in brain tissue. N-SMase activity has been implicated in many physiological and pathological processes affecting the brain and nervous system. In this review, we discuss the proposed functions of N-SMase with a particular emphasis on its role in neurological disorders, such as age-related neurodegeneration, Alzheimer's disease, HIV-associated dementia, atherosclerosis, ischemia-reperfusion injury, and cancer.

Original language	English
Pages (from-to)	1137-1149
Number of pages	13
Journal	Neurochemical Research
Volume	37
Issue number	6
DOIs	https://doi.org/10.1007/s11064-011-0692-y
State	Published - Jun 2012

Keywords

Ceramide
Sphingolipids
Sphingomyelinases
Sphingosine

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title = "The roles of neutral sphingomyelinases in neurological pathologies",

abstract = "The neutral sphingomyelinases (N-SMases) are a group of Mg 2+-dependent enzymes with a pH optimum in the neutral range. N-SMases catalyze the conversion of sphingomyelin to ceramide and have been found particularly enriched in brain tissue. N-SMase activity has been implicated in many physiological and pathological processes affecting the brain and nervous system. In this review, we discuss the proposed functions of N-SMase with a particular emphasis on its role in neurological disorders, such as age-related neurodegeneration, Alzheimer's disease, HIV-associated dementia, atherosclerosis, ischemia-reperfusion injury, and cancer.",

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AU - Horres, Charles R.

AU - Hannun, Yusuf A.

PY - 2012/6

Y1 - 2012/6

N2 - The neutral sphingomyelinases (N-SMases) are a group of Mg 2+-dependent enzymes with a pH optimum in the neutral range. N-SMases catalyze the conversion of sphingomyelin to ceramide and have been found particularly enriched in brain tissue. N-SMase activity has been implicated in many physiological and pathological processes affecting the brain and nervous system. In this review, we discuss the proposed functions of N-SMase with a particular emphasis on its role in neurological disorders, such as age-related neurodegeneration, Alzheimer's disease, HIV-associated dementia, atherosclerosis, ischemia-reperfusion injury, and cancer.

AB - The neutral sphingomyelinases (N-SMases) are a group of Mg 2+-dependent enzymes with a pH optimum in the neutral range. N-SMases catalyze the conversion of sphingomyelin to ceramide and have been found particularly enriched in brain tissue. N-SMase activity has been implicated in many physiological and pathological processes affecting the brain and nervous system. In this review, we discuss the proposed functions of N-SMase with a particular emphasis on its role in neurological disorders, such as age-related neurodegeneration, Alzheimer's disease, HIV-associated dementia, atherosclerosis, ischemia-reperfusion injury, and cancer.

KW - Ceramide

KW - Sphingolipids

KW - Sphingomyelinases

KW - Sphingosine

UR - https://www.scopus.com/pages/publications/84862861650

U2 - 10.1007/s11064-011-0692-y

DO - 10.1007/s11064-011-0692-y

M3 - Review article

C2 - 22237969

AN - SCOPUS:84862861650

SN - 0364-3190

VL - 37

SP - 1137

EP - 1149

JO - Neurochemical Research

JF - Neurochemical Research

IS - 6

ER -

The roles of neutral sphingomyelinases in neurological pathologies

Abstract

Keywords

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