Thermolysis and radiofluorination of diaryliodonium salts derived from anilines

Ethan J. Linstad; Amy L. Vāvere; Bao Hu; Jayson J. Kempinger; Scott E. Snyder; Stephen G. DiMagno

doi:10.1039/c7ob00253j

Thermolysis and radiofluorination of diaryliodonium salts derived from anilines

Ethan J. Linstad
, Amy L. Vāvere
, Bao Hu
, Jayson J. Kempinger
, Scott E. Snyder
, Stephen G. DiMagno

Psychiatry

University of Nebraska-Lincoln
University of Illinois at Chicago
St. Jude Children Research Hospital

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Aniline-derived diaryliodonium salts were synthesized and functionalized in good to excellent yields by judicious utilization of electron-withdrawing protecting groups. This simple approach opens another route to radiolabeling amino arenes in relatively complex molecules, such as flutemetamol.

Original language	English
Pages (from-to)	2246-2252
Number of pages	7
Journal	Organic and Biomolecular Chemistry
Volume	15
Issue number	10
DOIs	https://doi.org/10.1039/c7ob00253j
State	Published - 2017

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title = "Thermolysis and radiofluorination of diaryliodonium salts derived from anilines",

abstract = "Aniline-derived diaryliodonium salts were synthesized and functionalized in good to excellent yields by judicious utilization of electron-withdrawing protecting groups. This simple approach opens another route to radiolabeling amino arenes in relatively complex molecules, such as flutemetamol.",

author = "Linstad, \{Ethan J.\} and Vāvere, \{Amy L.\} and Bao Hu and Kempinger, \{Jayson J.\} and Snyder, \{Scott E.\} and DiMagno, \{Stephen G.\}",

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doi = "10.1039/c7ob00253j",

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T1 - Thermolysis and radiofluorination of diaryliodonium salts derived from anilines

AU - Linstad, Ethan J.

AU - Vāvere, Amy L.

AU - Hu, Bao

AU - Kempinger, Jayson J.

AU - Snyder, Scott E.

AU - DiMagno, Stephen G.

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2017

Y1 - 2017

N2 - Aniline-derived diaryliodonium salts were synthesized and functionalized in good to excellent yields by judicious utilization of electron-withdrawing protecting groups. This simple approach opens another route to radiolabeling amino arenes in relatively complex molecules, such as flutemetamol.

AB - Aniline-derived diaryliodonium salts were synthesized and functionalized in good to excellent yields by judicious utilization of electron-withdrawing protecting groups. This simple approach opens another route to radiolabeling amino arenes in relatively complex molecules, such as flutemetamol.

UR - https://www.scopus.com/pages/publications/85015041044

U2 - 10.1039/c7ob00253j

DO - 10.1039/c7ob00253j

M3 - Article

C2 - 28230886

AN - SCOPUS:85015041044

SN - 1477-0520

VL - 15

SP - 2246

EP - 2252

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 10

ER -

Thermolysis and radiofluorination of diaryliodonium salts derived from anilines

Abstract

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