@inproceedings{5cf9fa4ec1f44ff4ace3aa919f480949,
title = "Three-dimensional data analytics for pathology imaging",
abstract = "Three-dimensional (3D) structural changes and spatial relationships of micro-anatomic objects in whole-slide digital pathology images encode a large wealth of information on normal tissue development and disease progression. In this paper, we present a complete framework for quantitative spatial analytics of 3D micro-anatomic objects with pathology image volumes, with special focus on vessels and nuclei. Reconstructing 3D vessel structures from a sequence of whole-slide images, we simulate 3D biological systems by generating 3D nuclei uniformly distributed around 3D vessels. Given nuclei are distributed around vessels, intersection detection with 3D nuclei and vessels is conducted by a heuristic algorithm with data structure Axis-Aligned Bounding-Box (AABB). Motivated by real-world use case, we also travel the AABB tree constructed from 3D vessel structures to perform the distance based query between 3D nuclei and vessels. We quantitatively evaluate the performance of 3D intersection detection by the heuristic algorithm and distance-based query based on AABB tree traversal. Experimental results demonstrate the efficiency of our framework for 3D spatial analytics with whole-slide serial pathology image dataset.",
keywords = "3D data simulation, AABB tree, Distance-base query, Pathology imaging, Spatial analytics",
author = "Yanhui Liang and Jun Kong and Yangyang Zhu and Fusheng Wang",
note = "Publisher Copyright: {\textcopyright} Springer International Publishing Switzerland 2016.; 1st International Workshop on Data Management and Analytics for Medicine and Healthcare, DMAH 2015 and Workshop on Big-Graphs Online Querying, Big-O(Q) 2015 held in conjunction with 41st International Conference on Very Large Data Bases, VLDB 2015 ; Conference date: 31-08-2015 Through 04-09-2015",
year = "2016",
doi = "10.1007/978-3-319-41576-5\_8",
language = "English",
isbn = "9783319415758",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
publisher = "Springer Verlag",
pages = "109--125",
editor = "Arijit Khan and Gang Luo and Chunhua Weng and Fusheng Wang and Prasenjit Mitra and Cong Yu",
booktitle = "Biomedical Data Management and Graph Online Querying - VLDB 2015 Workshops, Big-O(Q) and DMAH, Revised Selected Papers",
}