TY - JOUR
T1 - Tooth Agenesis Patterns in Orofacial Clefting Using Tooth Agenesis Code
T2 - A Meta-Analysis
AU - Howe, Brian J.
AU - Pendleton, Chandler
AU - Withanage, Miyuraj Harishchandra Hikkaduwa
AU - Childs, Christopher A.
AU - Zeng, Erliang
AU - van Wijk, Arjen
AU - Hermus, Ruurd
AU - Padilla, Carmencita
AU - Hecht, Jacqueline T.
AU - Poletta, Fernando A.
AU - Orioli, Iêda M.
AU - Buxó-Martínez, Carmen J.
AU - Deleyiannis, Frederic
AU - Vieira, Alexandre R.
AU - Butali, Azeez
AU - Valencia-Ramirez, Consuelo
AU - Muñeton, Claudia Restrepo
AU - Wehby, George L.
AU - Weinberg, Seth M.
AU - Marazita, Mary L.
AU - Uribe, Lina M.Moreno
AU - Xie, Xian Jin
N1 - Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/7
Y1 - 2022/7
N2 - Individuals with orofacial clefting (OFC) have a higher prevalence of tooth agenesis (TA) overall. Neither the precise etiology of TA, nor whether TA occurs in patterns that differ by gender or cleft type is yet known. This meta-analysis aims to identify the spectrum of tooth agenesis patterns in subjects with non-syndromic OFC and controls using the Tooth Agenesis Code (TAC) program. An indexed search of databases (PubMed, EMBASE, and CINAHL) along with cross-referencing and hand searches were completed from May to June 2019 and re-run in February 2022. Additionally, unpublished TAC data from 914 individuals with OFC and 932 controls were included. TAC pattern frequencies per study were analyzed using a random effects meta-analysis model. A thorough review of 45 records retrieved resulted in 4 articles meeting eligibility criteria, comprising 2182 subjects with OFC and 3171 controls. No TA (0.0.0.0) was seen in 51% of OFC cases and 97% of controls. TAC patterns 0.2.0.0, 2.0.0.0, and 2.2.0.0 indicating uni-or bi-lateral missing upper laterals, and 16.0.0.0 indicating missing upper right second premolar, were more common in subjects with OFC. Subjects with OFC have unique TA patterns and defining these patterns will help increase our understanding of the complex etiology underlying TA.
AB - Individuals with orofacial clefting (OFC) have a higher prevalence of tooth agenesis (TA) overall. Neither the precise etiology of TA, nor whether TA occurs in patterns that differ by gender or cleft type is yet known. This meta-analysis aims to identify the spectrum of tooth agenesis patterns in subjects with non-syndromic OFC and controls using the Tooth Agenesis Code (TAC) program. An indexed search of databases (PubMed, EMBASE, and CINAHL) along with cross-referencing and hand searches were completed from May to June 2019 and re-run in February 2022. Additionally, unpublished TAC data from 914 individuals with OFC and 932 controls were included. TAC pattern frequencies per study were analyzed using a random effects meta-analysis model. A thorough review of 45 records retrieved resulted in 4 articles meeting eligibility criteria, comprising 2182 subjects with OFC and 3171 controls. No TA (0.0.0.0) was seen in 51% of OFC cases and 97% of controls. TAC patterns 0.2.0.0, 2.0.0.0, and 2.2.0.0 indicating uni-or bi-lateral missing upper laterals, and 16.0.0.0 indicating missing upper right second premolar, were more common in subjects with OFC. Subjects with OFC have unique TA patterns and defining these patterns will help increase our understanding of the complex etiology underlying TA.
KW - cleft lip and palate
KW - hypodontia
KW - machine learning
KW - phenotype
UR - https://www.scopus.com/pages/publications/85133844939
U2 - 10.3390/dj10070128
DO - 10.3390/dj10070128
M3 - Review article
AN - SCOPUS:85133844939
SN - 2304-6767
VL - 10
JO - Dentistry Journal
JF - Dentistry Journal
IS - 7
M1 - 128
ER -