Transcriptional Silencers in Drosophila Serve a Dual Role as Transcriptional Enhancers in Alternate Cellular Contexts

Stephen S. Gisselbrecht; Alexandre Palagi; Jesse V. Kurland; Julia M. Rogers; Hakan Ozadam; Ye Zhan; Job Dekker; Martha L. Bulyk

doi:10.1016/j.molcel.2019.10.004

Transcriptional Silencers in Drosophila Serve a Dual Role as Transcriptional Enhancers in Alternate Cellular Contexts

Stephen S. Gisselbrecht
, Alexandre Palagi
, Jesse V. Kurland
, Julia M. Rogers
, Hakan Ozadam
, Ye Zhan
, Job Dekker
, Martha L. Bulyk

Biochemistry and Cell Biology

Brigham and Women’s Hospital
Université Côte d'Azur
University of Massachusetts Medical School
Howard Hughes Medical Institute
Harvard University

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

Gisselbrecht et al. performed a screen in developing Drosophila embryos for genomic sequences that can act as transcriptional silencers. They report that nearly all silencers are enhancers in other tissues or at other developmental stages. Their silencers fall into two classes, one of which forms physical chromosomal contacts with promoters.

Original language	English
Pages (from-to)	324-337.e8
Journal	Molecular Cell
Volume	77
Issue number	2
DOIs	https://doi.org/10.1016/j.molcel.2019.10.004
State	Published - Jan 16 2020

Keywords

cis-regulatory elements
enhancers
promoter looping
repression
silencers
transcriptional regulation

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10.1016/j.molcel.2019.10.004

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title = "Transcriptional Silencers in Drosophila Serve a Dual Role as Transcriptional Enhancers in Alternate Cellular Contexts",

abstract = "Gisselbrecht et al. performed a screen in developing Drosophila embryos for genomic sequences that can act as transcriptional silencers. They report that nearly all silencers are enhancers in other tissues or at other developmental stages. Their silencers fall into two classes, one of which forms physical chromosomal contacts with promoters.",

keywords = "cis-regulatory elements, enhancers, promoter looping, repression, silencers, transcriptional regulation",

author = "Gisselbrecht, \{Stephen S.\} and Alexandre Palagi and Kurland, \{Jesse V.\} and Rogers, \{Julia M.\} and Hakan Ozadam and Ye Zhan and Job Dekker and Bulyk, \{Martha L.\}",

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AU - Gisselbrecht, Stephen S.

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AU - Rogers, Julia M.

AU - Ozadam, Hakan

AU - Zhan, Ye

AU - Dekker, Job

AU - Bulyk, Martha L.

PY - 2020/1/16

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AB - Gisselbrecht et al. performed a screen in developing Drosophila embryos for genomic sequences that can act as transcriptional silencers. They report that nearly all silencers are enhancers in other tissues or at other developmental stages. Their silencers fall into two classes, one of which forms physical chromosomal contacts with promoters.

KW - cis-regulatory elements

KW - enhancers

KW - promoter looping

KW - repression

KW - silencers

KW - transcriptional regulation

UR - https://www.scopus.com/pages/publications/85077575346

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ER -

Transcriptional Silencers in Drosophila Serve a Dual Role as Transcriptional Enhancers in Alternate Cellular Contexts

Abstract

Keywords

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