Transdiagnostic Psychopathology Factors and Sexual Minority Mental Health: Evidence of Disparities and Associations With Minority Stressors

Research on mental health disparities between sexual minority individuals and heterosexuals has traditionally taken a disorder-by-disorder approach. Recently developed transdiagnostic approaches provide a new method to frame such investigations; however, transdiagnostic factors have yet to be applied to sexual minority mental health disparities research. The current study applied this methodology to investigate mental health disparities between lesbian, gay, bisexual, and heterosexual individuals in a large national probability sample (N 34,653). Twelve-month diagnoses of 13 common mood, anxiety, substance use, and personality disorders were modeled, and multigroup analysis indicated a sexual orientation-invariant transdiagnostic latent structure. Significant disparities at the latent transdiagnostic factor level were observed; these factor-level disparities are manifested as observed mental disorder disparities. Gender differences typically seen in transdiagnostic research were not present between sexual minority women and men. Transdiagnostic internalizing and externalizing factors were then used as outcomes in a minority stress framework and were positively predicted by lifetime history of sexual orientation-related minority stressors (i.e., discrimination and victimization). Implications for using transdiagnostic approaches to frame intervention efforts, supplement disorder-by-disorder disparities methodologies, and synthesize piecemeal disparities literatures are discussed.