Traumatic exposures, posttraumatic stress disorder, and cognitive functioning in World Trade Center responders

Sean Clouston; Robert H. Pietrzak; Roman Kotov; Marcus Richards; Avron Spiro; Stacey Scott; Yael Deri; Soumyadeep Mukherjee; Candace Stewart; Evelyn Bromet; Benjamin J. Luft

doi:10.1016/j.trci.2017.09.001

Traumatic exposures, posttraumatic stress disorder, and cognitive functioning in World Trade Center responders

Sean Clouston
, Robert H. Pietrzak
, Roman Kotov
, Marcus Richards
, Avron Spiro
, Stacey Scott
, Yael Deri
, Soumyadeep Mukherjee
, Candace Stewart
, Evelyn Bromet
, Benjamin J. Luft

Yale University
University College London
Boston University
Stony Brook University

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Introduction This study examined whether World Trade Center (WTC)-related exposures and posttraumatic stress disorder (PTSD) were associated with cognitive function and whether WTC responders' cognition differed from normative data. Methods A computer-assisted neuropsychological battery was administered to a prospective cohort study of 1193 WTC responders with no history of stroke or WTC-related head injuries. Data were linked to information collected prospectively since 2002. Sample averages were compared to published norms. Results Approximately 14.8% of sampled responders had cognitive dysfunction. WTC responders had worse cognitive function compared to normative data. PTSD symptom severity and working >5 weeks on-site was associated with lower cognition. Discussion Results from this sample highlight the potential for WTC responders to be experiencing an increased burden of cognitive dysfunction and linked lowered cognitive functioning to physical exposures and to PTSD. Future research is warranted to understand the extent to which cognitive dysfunction is evident in neural dysfunction.

Original language	English
Pages (from-to)	593-602
Number of pages	10
Journal	Alzheimer's and Dementia: Translational Research and Clinical Interventions
Volume	3
Issue number	4
DOIs	https://doi.org/10.1016/j.trci.2017.09.001
State	Published - Nov 2017

Keywords

Cognitive dysfunction
Particulate exposure
Posttraumatic stress disorder
Trauma
World Trade Center

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Clouston, S., Pietrzak, R. H., Kotov, R., Richards, M., Spiro, A., Scott, S., Deri, Y., Mukherjee, S., Stewart, C., Bromet, E., & Luft, B. J. (2017). Traumatic exposures, posttraumatic stress disorder, and cognitive functioning in World Trade Center responders. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 3(4), 593-602. https://doi.org/10.1016/j.trci.2017.09.001

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title = "Traumatic exposures, posttraumatic stress disorder, and cognitive functioning in World Trade Center responders",

abstract = "Introduction This study examined whether World Trade Center (WTC)-related exposures and posttraumatic stress disorder (PTSD) were associated with cognitive function and whether WTC responders' cognition differed from normative data. Methods A computer-assisted neuropsychological battery was administered to a prospective cohort study of 1193 WTC responders with no history of stroke or WTC-related head injuries. Data were linked to information collected prospectively since 2002. Sample averages were compared to published norms. Results Approximately 14.8\% of sampled responders had cognitive dysfunction. WTC responders had worse cognitive function compared to normative data. PTSD symptom severity and working >5 weeks on-site was associated with lower cognition. Discussion Results from this sample highlight the potential for WTC responders to be experiencing an increased burden of cognitive dysfunction and linked lowered cognitive functioning to physical exposures and to PTSD. Future research is warranted to understand the extent to which cognitive dysfunction is evident in neural dysfunction.",

keywords = "Cognitive dysfunction, Particulate exposure, Posttraumatic stress disorder, Trauma, World Trade Center",

author = "Sean Clouston and Pietrzak, \{Robert H.\} and Roman Kotov and Marcus Richards and Avron Spiro and Stacey Scott and Yael Deri and Soumyadeep Mukherjee and Candace Stewart and Evelyn Bromet and Luft, \{Benjamin J.\}",

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doi = "10.1016/j.trci.2017.09.001",

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Clouston, S, Pietrzak, RH, Kotov, R, Richards, M, Spiro, A, Scott, S, Deri, Y, Mukherjee, S, Stewart, C, Bromet, E & Luft, BJ 2017, 'Traumatic exposures, posttraumatic stress disorder, and cognitive functioning in World Trade Center responders', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 3, no. 4, pp. 593-602. https://doi.org/10.1016/j.trci.2017.09.001

TY - JOUR

T1 - Traumatic exposures, posttraumatic stress disorder, and cognitive functioning in World Trade Center responders

AU - Clouston, Sean

AU - Pietrzak, Robert H.

AU - Kotov, Roman

AU - Richards, Marcus

AU - Spiro, Avron

AU - Scott, Stacey

AU - Deri, Yael

AU - Mukherjee, Soumyadeep

AU - Stewart, Candace

AU - Bromet, Evelyn

AU - Luft, Benjamin J.

PY - 2017/11

Y1 - 2017/11

N2 - Introduction This study examined whether World Trade Center (WTC)-related exposures and posttraumatic stress disorder (PTSD) were associated with cognitive function and whether WTC responders' cognition differed from normative data. Methods A computer-assisted neuropsychological battery was administered to a prospective cohort study of 1193 WTC responders with no history of stroke or WTC-related head injuries. Data were linked to information collected prospectively since 2002. Sample averages were compared to published norms. Results Approximately 14.8% of sampled responders had cognitive dysfunction. WTC responders had worse cognitive function compared to normative data. PTSD symptom severity and working >5 weeks on-site was associated with lower cognition. Discussion Results from this sample highlight the potential for WTC responders to be experiencing an increased burden of cognitive dysfunction and linked lowered cognitive functioning to physical exposures and to PTSD. Future research is warranted to understand the extent to which cognitive dysfunction is evident in neural dysfunction.

AB - Introduction This study examined whether World Trade Center (WTC)-related exposures and posttraumatic stress disorder (PTSD) were associated with cognitive function and whether WTC responders' cognition differed from normative data. Methods A computer-assisted neuropsychological battery was administered to a prospective cohort study of 1193 WTC responders with no history of stroke or WTC-related head injuries. Data were linked to information collected prospectively since 2002. Sample averages were compared to published norms. Results Approximately 14.8% of sampled responders had cognitive dysfunction. WTC responders had worse cognitive function compared to normative data. PTSD symptom severity and working >5 weeks on-site was associated with lower cognition. Discussion Results from this sample highlight the potential for WTC responders to be experiencing an increased burden of cognitive dysfunction and linked lowered cognitive functioning to physical exposures and to PTSD. Future research is warranted to understand the extent to which cognitive dysfunction is evident in neural dysfunction.

KW - Cognitive dysfunction

KW - Particulate exposure

KW - Posttraumatic stress disorder

KW - Trauma

KW - World Trade Center

UR - https://www.scopus.com/pages/publications/85034421713

U2 - 10.1016/j.trci.2017.09.001

DO - 10.1016/j.trci.2017.09.001

M3 - Article

AN - SCOPUS:85034421713

SN - 2352-8737

VL - 3

SP - 593

EP - 602

JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions

JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions

IS - 4

ER -

Traumatic exposures, posttraumatic stress disorder, and cognitive functioning in World Trade Center responders

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