Tumor necrosis factor (TNF) and lymphotoxin-α (LTA) polymorphisms and risk of non-hodgkin lymphoma in the interLymph consortium

Christine F. Skibola; Paige M. Bracci; Alexandra Nieters; Angela Brooks-Wilson; Silvia De Sanjosé; Ann Maree Hughes; James R. Cerhan; Danica R. Skibola; Mark Purdue; Eleanor Kane; Qing Lan; Lenka Foretova; Maryjean Schenk; John J. Spinelli; Susan L. Slager; Anneclaire J. De Roos; Martyn T. Smith; Eve Roman; Wendy Cozen; Paolo Boffetta; Anne Kricker; Tongzhang Zheng; Tracy Lightfoot; Pierluigi Cocco; Yolanda Benavente; Yawei Zhang; Patricia Hartge; Martha S. Linet; Nikolaus Becker; Paul Brennan; Luoping Zhang; Bruce Armstrong; Alex Smith; Renee Shiao; Anne J. Novak; Marc Maynadie; Stephen J. Chanock; Anthony Staines; Theodore R. Holford; Elizabeth A. Holly; Nathaniel Rothman; Sophia S. Wang

doi:10.1093/aje/kwp383

Tumor necrosis factor (TNF) and lymphotoxin-α (LTA) polymorphisms and risk of non-hodgkin lymphoma in the interLymph consortium

Christine F. Skibola
, Paige M. Bracci
, Alexandra Nieters
, Angela Brooks-Wilson
, Silvia De Sanjosé
, Ann Maree Hughes
, James R. Cerhan
, Danica R. Skibola
, Mark Purdue
, Eleanor Kane
, Qing Lan
, Lenka Foretova
, Maryjean Schenk
, John J. Spinelli
, Susan L. Slager
, Anneclaire J. De Roos
, Martyn T. Smith
, Eve Roman
, Wendy Cozen
, Paolo Boffetta

Anne Kricker, Tongzhang Zheng, Tracy Lightfoot, Pierluigi Cocco, Yolanda Benavente, Yawei Zhang, Patricia Hartge, Martha S. Linet, Nikolaus Becker, Paul Brennan, Luoping Zhang, Bruce Armstrong, Alex Smith, Renee Shiao, Anne J. Novak, Marc Maynadie, Stephen J. Chanock, Anthony Staines, Theodore R. Holford, Elizabeth A. Holly, Nathaniel Rothman, Sophia S. Wang

Family , Population and Preventative Medicine

University of California at Berkeley
University of California at San Francisco
German Cancer Research Center
Provincial Health Services Authority
Simon Fraser University
Institute Catala Oncologia
The University of Sydney
Mayo Clinic Rochester, MN
National Institutes of Health
University of York
Yale University
Masaryk Memorial Cancer Institute
Wayne State University
University of Southern California
University of Cagliari
International Agency for Research on Cancer
Université de Bourgogne
Dublin City University
Division of Etiology

Research output: Contribution to journal › Article › peer-review

130 Scopus citations

Abstract

In an International Lymphoma Epidemiology Consortium pooled analysis, polymorphisms in 2 immune-system-related genes, tumor necrosis factor (TNF) and interleukin-10 (IL10), were associated with non-Hodgkin lymphoma (NHL) risk. Here, 8,847 participants were added to previous data (patients diagnosed from 1989 to 2005 in 14 case-control studies; 7,999 cases, 8,452 controls) for testing of polymorphisms in the TNF-308G>A (rs1800629), lymphotoxin-α (LTA) 252A>G (rs909253), IL10-3575T>A (rs1800890, rs1800896), and nucleotide-binding oligomerization domain containing 2 (NOD2) 3020insC (rs2066847) genes. Odds ratios were estimated for non-Hispanic whites and several ethnic subgroups using 2-sided tests. Consistent with previous findings, odds ratios were increased for "new" participant TNF-308A carriers (NHL: per-allele odds ratio (ORallelic)=1.10, Ptrend=0.001; diffuse large B-cell lymphoma (DLBCL): ORallelic=1.23, Ptrend=0.004). In the combined population, odds ratios were increased for TNF-308A carriers (NHL: ORallelic=1.13, Ptrend=0.0001; DLBCL: ORallelic=1.25, Ptrend=3.7 × 10^-6; marginal zone lymphoma: ORallelic=1.35, Ptrend=0.004) and LTA 252G carriers (DLBCL: ORallelic=1.12, Ptrend = 0.006; mycosis fungoides: ORallelic=1.44, Ptrend=0.015). The LTA 252A>G/TNF-308G>A haplotype containing the LTA/TNF variant alleles was strongly associated with DLBCL (P=2.9 × 10 ^-8). Results suggested associations between IL10-3575T>A and DLBCL (Ptrend=0.02) and IL10-1082A>G and mantle cell lymphoma (Ptrend=0.04). These findings strengthen previous results for DLBCL and the LTA 252A>G/TNF-308A locus and provide robust evidence that these TNF/LTA gene variants, or others in linkage disequilibrium, are involved in NHL etiology.

Original language	English
Pages (from-to)	267-276
Number of pages	10
Journal	American Journal of Epidemiology
Volume	171
Issue number	3
DOIs	https://doi.org/10.1093/aje/kwp383
State	Published - Feb 2010

Keywords

Lymphoma
Lymphoma, non-Hodgkin
Lymphotoxin-alpha
Meta-analysis
Polymorphism, genetic
Polymorphism, single nucleotide
Tumor necrosis factor-alpha

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10.1093/aje/kwp383

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Skibola, C. F., Bracci, P. M., Nieters, A., Brooks-Wilson, A., De Sanjosé, S., Hughes, A. M., Cerhan, J. R., Skibola, D. R., Purdue, M., Kane, E., Lan, Q., Foretova, L., Schenk, M., Spinelli, J. J., Slager, S. L., De Roos, A. J., Smith, M. T., Roman, E., Cozen, W., ... Wang, S. S. (2010). Tumor necrosis factor (TNF) and lymphotoxin-α (LTA) polymorphisms and risk of non-hodgkin lymphoma in the interLymph consortium. American Journal of Epidemiology, 171(3), 267-276. https://doi.org/10.1093/aje/kwp383

@article{184fe85771b046a19a19a75fa927b267,

title = "Tumor necrosis factor (TNF) and lymphotoxin-α (LTA) polymorphisms and risk of non-hodgkin lymphoma in the interLymph consortium",

abstract = "In an International Lymphoma Epidemiology Consortium pooled analysis, polymorphisms in 2 immune-system-related genes, tumor necrosis factor (TNF) and interleukin-10 (IL10), were associated with non-Hodgkin lymphoma (NHL) risk. Here, 8,847 participants were added to previous data (patients diagnosed from 1989 to 2005 in 14 case-control studies; 7,999 cases, 8,452 controls) for testing of polymorphisms in the TNF-308G>A (rs1800629), lymphotoxin-α (LTA) 252A>G (rs909253), IL10-3575T>A (rs1800890, rs1800896), and nucleotide-binding oligomerization domain containing 2 (NOD2) 3020insC (rs2066847) genes. Odds ratios were estimated for non-Hispanic whites and several ethnic subgroups using 2-sided tests. Consistent with previous findings, odds ratios were increased for {"}new{"} participant TNF-308A carriers (NHL: per-allele odds ratio (ORallelic)=1.10, Ptrend=0.001; diffuse large B-cell lymphoma (DLBCL): ORallelic=1.23, Ptrend=0.004). In the combined population, odds ratios were increased for TNF-308A carriers (NHL: ORallelic=1.13, Ptrend=0.0001; DLBCL: ORallelic=1.25, Ptrend=3.7 × 10-6; marginal zone lymphoma: ORallelic=1.35, Ptrend=0.004) and LTA 252G carriers (DLBCL: ORallelic=1.12, Ptrend = 0.006; mycosis fungoides: ORallelic=1.44, Ptrend=0.015). The LTA 252A>G/TNF-308G>A haplotype containing the LTA/TNF variant alleles was strongly associated with DLBCL (P=2.9 × 10 -8). Results suggested associations between IL10-3575T>A and DLBCL (Ptrend=0.02) and IL10-1082A>G and mantle cell lymphoma (Ptrend=0.04). These findings strengthen previous results for DLBCL and the LTA 252A>G/TNF-308A locus and provide robust evidence that these TNF/LTA gene variants, or others in linkage disequilibrium, are involved in NHL etiology.",

keywords = "Lymphoma, Lymphoma, non-Hodgkin, Lymphotoxin-alpha, Meta-analysis, Polymorphism, genetic, Polymorphism, single nucleotide, Tumor necrosis factor-alpha",

author = "Skibola, \{Christine F.\} and Bracci, \{Paige M.\} and Alexandra Nieters and Angela Brooks-Wilson and \{De Sanjos{\'e}\}, Silvia and Hughes, \{Ann Maree\} and Cerhan, \{James R.\} and Skibola, \{Danica R.\} and Mark Purdue and Eleanor Kane and Qing Lan and Lenka Foretova and Maryjean Schenk and Spinelli, \{John J.\} and Slager, \{Susan L.\} and \{De Roos\}, \{Anneclaire J.\} and Smith, \{Martyn T.\} and Eve Roman and Wendy Cozen and Paolo Boffetta and Anne Kricker and Tongzhang Zheng and Tracy Lightfoot and Pierluigi Cocco and Yolanda Benavente and Yawei Zhang and Patricia Hartge and Linet, \{Martha S.\} and Nikolaus Becker and Paul Brennan and Luoping Zhang and Bruce Armstrong and Alex Smith and Renee Shiao and Novak, \{Anne J.\} and Marc Maynadie and Chanock, \{Stephen J.\} and Anthony Staines and Holford, \{Theodore R.\} and Holly, \{Elizabeth A.\} and Nathaniel Rothman and Wang, \{Sophia S.\}",

year = "2010",

month = feb,

doi = "10.1093/aje/kwp383",

language = "English",

volume = "171",

pages = "267--276",

journal = "American Journal of Epidemiology",

issn = "0002-9262",

number = "3",

}

Skibola, CF, Bracci, PM, Nieters, A, Brooks-Wilson, A, De Sanjosé, S, Hughes, AM, Cerhan, JR, Skibola, DR, Purdue, M, Kane, E, Lan, Q, Foretova, L, Schenk, M, Spinelli, JJ, Slager, SL, De Roos, AJ, Smith, MT, Roman, E, Cozen, W, Boffetta, P, Kricker, A, Zheng, T, Lightfoot, T, Cocco, P, Benavente, Y, Zhang, Y, Hartge, P, Linet, MS, Becker, N, Brennan, P, Zhang, L, Armstrong, B, Smith, A, Shiao, R, Novak, AJ, Maynadie, M, Chanock, SJ, Staines, A, Holford, TR, Holly, EA, Rothman, N & Wang, SS 2010, 'Tumor necrosis factor (TNF) and lymphotoxin-α (LTA) polymorphisms and risk of non-hodgkin lymphoma in the interLymph consortium', American Journal of Epidemiology, vol. 171, no. 3, pp. 267-276. https://doi.org/10.1093/aje/kwp383

TY - JOUR

T1 - Tumor necrosis factor (TNF) and lymphotoxin-α (LTA) polymorphisms and risk of non-hodgkin lymphoma in the interLymph consortium

AU - Skibola, Christine F.

AU - Bracci, Paige M.

AU - Nieters, Alexandra

AU - Brooks-Wilson, Angela

AU - De Sanjosé, Silvia

AU - Hughes, Ann Maree

AU - Cerhan, James R.

AU - Skibola, Danica R.

AU - Purdue, Mark

AU - Kane, Eleanor

AU - Lan, Qing

AU - Foretova, Lenka

AU - Schenk, Maryjean

AU - Spinelli, John J.

AU - Slager, Susan L.

AU - De Roos, Anneclaire J.

AU - Smith, Martyn T.

AU - Roman, Eve

AU - Cozen, Wendy

AU - Boffetta, Paolo

AU - Kricker, Anne

AU - Zheng, Tongzhang

AU - Lightfoot, Tracy

AU - Cocco, Pierluigi

AU - Benavente, Yolanda

AU - Zhang, Yawei

AU - Hartge, Patricia

AU - Linet, Martha S.

AU - Becker, Nikolaus

AU - Brennan, Paul

AU - Zhang, Luoping

AU - Armstrong, Bruce

AU - Smith, Alex

AU - Shiao, Renee

AU - Novak, Anne J.

AU - Maynadie, Marc

AU - Chanock, Stephen J.

AU - Staines, Anthony

AU - Holford, Theodore R.

AU - Holly, Elizabeth A.

AU - Rothman, Nathaniel

AU - Wang, Sophia S.

PY - 2010/2

Y1 - 2010/2

N2 - In an International Lymphoma Epidemiology Consortium pooled analysis, polymorphisms in 2 immune-system-related genes, tumor necrosis factor (TNF) and interleukin-10 (IL10), were associated with non-Hodgkin lymphoma (NHL) risk. Here, 8,847 participants were added to previous data (patients diagnosed from 1989 to 2005 in 14 case-control studies; 7,999 cases, 8,452 controls) for testing of polymorphisms in the TNF-308G>A (rs1800629), lymphotoxin-α (LTA) 252A>G (rs909253), IL10-3575T>A (rs1800890, rs1800896), and nucleotide-binding oligomerization domain containing 2 (NOD2) 3020insC (rs2066847) genes. Odds ratios were estimated for non-Hispanic whites and several ethnic subgroups using 2-sided tests. Consistent with previous findings, odds ratios were increased for "new" participant TNF-308A carriers (NHL: per-allele odds ratio (ORallelic)=1.10, Ptrend=0.001; diffuse large B-cell lymphoma (DLBCL): ORallelic=1.23, Ptrend=0.004). In the combined population, odds ratios were increased for TNF-308A carriers (NHL: ORallelic=1.13, Ptrend=0.0001; DLBCL: ORallelic=1.25, Ptrend=3.7 × 10-6; marginal zone lymphoma: ORallelic=1.35, Ptrend=0.004) and LTA 252G carriers (DLBCL: ORallelic=1.12, Ptrend = 0.006; mycosis fungoides: ORallelic=1.44, Ptrend=0.015). The LTA 252A>G/TNF-308G>A haplotype containing the LTA/TNF variant alleles was strongly associated with DLBCL (P=2.9 × 10 -8). Results suggested associations between IL10-3575T>A and DLBCL (Ptrend=0.02) and IL10-1082A>G and mantle cell lymphoma (Ptrend=0.04). These findings strengthen previous results for DLBCL and the LTA 252A>G/TNF-308A locus and provide robust evidence that these TNF/LTA gene variants, or others in linkage disequilibrium, are involved in NHL etiology.

AB - In an International Lymphoma Epidemiology Consortium pooled analysis, polymorphisms in 2 immune-system-related genes, tumor necrosis factor (TNF) and interleukin-10 (IL10), were associated with non-Hodgkin lymphoma (NHL) risk. Here, 8,847 participants were added to previous data (patients diagnosed from 1989 to 2005 in 14 case-control studies; 7,999 cases, 8,452 controls) for testing of polymorphisms in the TNF-308G>A (rs1800629), lymphotoxin-α (LTA) 252A>G (rs909253), IL10-3575T>A (rs1800890, rs1800896), and nucleotide-binding oligomerization domain containing 2 (NOD2) 3020insC (rs2066847) genes. Odds ratios were estimated for non-Hispanic whites and several ethnic subgroups using 2-sided tests. Consistent with previous findings, odds ratios were increased for "new" participant TNF-308A carriers (NHL: per-allele odds ratio (ORallelic)=1.10, Ptrend=0.001; diffuse large B-cell lymphoma (DLBCL): ORallelic=1.23, Ptrend=0.004). In the combined population, odds ratios were increased for TNF-308A carriers (NHL: ORallelic=1.13, Ptrend=0.0001; DLBCL: ORallelic=1.25, Ptrend=3.7 × 10-6; marginal zone lymphoma: ORallelic=1.35, Ptrend=0.004) and LTA 252G carriers (DLBCL: ORallelic=1.12, Ptrend = 0.006; mycosis fungoides: ORallelic=1.44, Ptrend=0.015). The LTA 252A>G/TNF-308G>A haplotype containing the LTA/TNF variant alleles was strongly associated with DLBCL (P=2.9 × 10 -8). Results suggested associations between IL10-3575T>A and DLBCL (Ptrend=0.02) and IL10-1082A>G and mantle cell lymphoma (Ptrend=0.04). These findings strengthen previous results for DLBCL and the LTA 252A>G/TNF-308A locus and provide robust evidence that these TNF/LTA gene variants, or others in linkage disequilibrium, are involved in NHL etiology.

KW - Lymphoma

KW - Lymphoma, non-Hodgkin

KW - Lymphotoxin-alpha

KW - Meta-analysis

KW - Polymorphism, genetic

KW - Polymorphism, single nucleotide

KW - Tumor necrosis factor-alpha

UR - https://www.scopus.com/pages/publications/75149123908

U2 - 10.1093/aje/kwp383

DO - 10.1093/aje/kwp383

M3 - Article

C2 - 20047977

AN - SCOPUS:75149123908

SN - 0002-9262

VL - 171

SP - 267

EP - 276

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

IS - 3

ER -

Tumor necrosis factor (TNF) and lymphotoxin-α (LTA) polymorphisms and risk of non-hodgkin lymphoma in the interLymph consortium

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Keywords

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