Ultrasound-driven megahertz Faraday waves for generation of monodisperse micro droplets and applications

Chen S. Tsai; Rong W. Mao; Shih K. Lin; Shirley C. Tsai; Gerry Boss; Matt Brenner; Gerry Smaldone; Sari Mahon; Kaveh Shahverdi; Yun Zhu

doi:10.1016/j.phpro.2015.08.179

Ultrasound-driven megahertz Faraday waves for generation of monodisperse micro droplets and applications

Chen S. Tsai
, Rong W. Mao
, Shih K. Lin
, Shirley C. Tsai
, Gerry Boss
, Matt Brenner
, Gerry Smaldone
, Sari Mahon
, Kaveh Shahverdi
, Yun Zhu

Pulmonary and Critical Care

University of California at Irvine
University of California at San Diego

Research output: Contribution to journal › Conference article › peer-review

4 Scopus citations

Abstract

Our theoretical findings on instability of Faraday waves at megahertz (MHz) drive frequency and realization of silicon-based MHz multiple-Fourier horn ultrasonic nozzles (MFHUNs) together have enabled generation of mono-disperse droplets of controllable diameter (2.5-6.0 μm) at very low electrical drive power (<0.5 Watt). The resulting battery-run clogging-free droplet generator has imminent application to pulmonary (inhalation) drug delivery and other potential applications. Here an update of advances on analysis and design of the MHz MFHUNs and the underlying physical mechanism for generation of mono-disperse micro droplets, and the nebulizer platform for application to detoxification of cyanide poisoning are presented.

Original language	English
Pages (from-to)	872-875
Number of pages	4
Journal	Physics Procedia
Volume	70
DOIs	https://doi.org/10.1016/j.phpro.2015.08.179
State	Published - 2015
Event	ICU International Congress on Ultrasonics, ICU 2015 - Metz, France Duration: May 11 2015 → May 14 2015

Keywords

Faraday instability
cyanide poisoning
monodisperse micro droplet
multiple-Fourier horns
pulmonary drug delivery

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10.1016/j.phpro.2015.08.179

Cite this

@article{77c775a1fad64219985d691e52a38332,

title = "Ultrasound-driven megahertz Faraday waves for generation of monodisperse micro droplets and applications",

abstract = "Our theoretical findings on instability of Faraday waves at megahertz (MHz) drive frequency and realization of silicon-based MHz multiple-Fourier horn ultrasonic nozzles (MFHUNs) together have enabled generation of mono-disperse droplets of controllable diameter (2.5-6.0 μm) at very low electrical drive power (<0.5 Watt). The resulting battery-run clogging-free droplet generator has imminent application to pulmonary (inhalation) drug delivery and other potential applications. Here an update of advances on analysis and design of the MHz MFHUNs and the underlying physical mechanism for generation of mono-disperse micro droplets, and the nebulizer platform for application to detoxification of cyanide poisoning are presented.",

keywords = "Faraday instability, cyanide poisoning, monodisperse micro droplet, multiple-Fourier horns, pulmonary drug delivery",

author = "Tsai, \{Chen S.\} and Mao, \{Rong W.\} and Lin, \{Shih K.\} and Tsai, \{Shirley C.\} and Gerry Boss and Matt Brenner and Gerry Smaldone and Sari Mahon and Kaveh Shahverdi and Yun Zhu",

note = "Publisher Copyright: {\textcopyright} 2015 The Authors.; ICU International Congress on Ultrasonics, ICU 2015 ; Conference date: 11-05-2015 Through 14-05-2015",

year = "2015",

doi = "10.1016/j.phpro.2015.08.179",

language = "English",

volume = "70",

pages = "872--875",

journal = "Physics Procedia",

issn = "1875-3884",

}

TY - JOUR

T1 - Ultrasound-driven megahertz Faraday waves for generation of monodisperse micro droplets and applications

AU - Tsai, Chen S.

AU - Mao, Rong W.

AU - Lin, Shih K.

AU - Tsai, Shirley C.

AU - Boss, Gerry

AU - Brenner, Matt

AU - Smaldone, Gerry

AU - Mahon, Sari

AU - Shahverdi, Kaveh

AU - Zhu, Yun

PY - 2015

Y1 - 2015

N2 - Our theoretical findings on instability of Faraday waves at megahertz (MHz) drive frequency and realization of silicon-based MHz multiple-Fourier horn ultrasonic nozzles (MFHUNs) together have enabled generation of mono-disperse droplets of controllable diameter (2.5-6.0 μm) at very low electrical drive power (<0.5 Watt). The resulting battery-run clogging-free droplet generator has imminent application to pulmonary (inhalation) drug delivery and other potential applications. Here an update of advances on analysis and design of the MHz MFHUNs and the underlying physical mechanism for generation of mono-disperse micro droplets, and the nebulizer platform for application to detoxification of cyanide poisoning are presented.

AB - Our theoretical findings on instability of Faraday waves at megahertz (MHz) drive frequency and realization of silicon-based MHz multiple-Fourier horn ultrasonic nozzles (MFHUNs) together have enabled generation of mono-disperse droplets of controllable diameter (2.5-6.0 μm) at very low electrical drive power (<0.5 Watt). The resulting battery-run clogging-free droplet generator has imminent application to pulmonary (inhalation) drug delivery and other potential applications. Here an update of advances on analysis and design of the MHz MFHUNs and the underlying physical mechanism for generation of mono-disperse micro droplets, and the nebulizer platform for application to detoxification of cyanide poisoning are presented.

KW - Faraday instability

KW - cyanide poisoning

KW - monodisperse micro droplet

KW - multiple-Fourier horns

KW - pulmonary drug delivery

UR - https://www.scopus.com/pages/publications/84948670324

U2 - 10.1016/j.phpro.2015.08.179

DO - 10.1016/j.phpro.2015.08.179

M3 - Conference article

AN - SCOPUS:84948670324

SN - 1875-3884

VL - 70

SP - 872

EP - 875

JO - Physics Procedia

JF - Physics Procedia

T2 - ICU International Congress on Ultrasonics, ICU 2015

Y2 - 11 May 2015 through 14 May 2015

ER -

Ultrasound-driven megahertz Faraday waves for generation of monodisperse micro droplets and applications

Abstract

Keywords

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