Vasculitic neuropathy: Review of diagnostic and therapeutic options

BACKGROUND- Approximately 20 to 25% of polyneuropathies are due to inflammatory disorders. Vasculitic neuropathies often present acutely in adults. The most distinctive feature is mononeuritis multiplex; however, this form accounts only for 10 to 15% of patients. Vasculitic neuropathy poses a diagnostic and therapeutic challenge to the clinical neurologist. SUMMARY- This article reviews the Vasculitic neuropathies, particularly regarding their diagnosis and therapeutic considerations. CONCLUSION- Vasculitic neuropathy, although a rare entity, has a distinct clinical and electrophysiological presentation. Tissue confirmation of necrotizing vasculitis is required in most cases of suspected vasculitis, particularly if long-term immunosuppressive drug therapy is considered. However, a negative biopsy should not delay the therapy, when other clinical features and laboratory studies are sufficient.