Way-100635 reverses 8-OH-DPAT-induced performance impairment in the radial maze

Scott Helsley; Tara L. Siegel; David Fiorella; Richard A. Rabin; J. C. Winter

doi:10.1016/S0278-5846(98)00068-2

Way-100635 reverses 8-OH-DPAT-induced performance impairment in the radial maze

Scott Helsley
, Tara L. Siegel
, David Fiorella
, Richard A. Rabin
, J. C. Winter

Surgery

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

1. The effects of the 5-HT(1A) receptor agonist, (8-OH-DPAT), alone and in combination with the selective 5-HT(1A) antagonist, WAY-100635, were assessed in Fischer-344 rats in an 8-arm radial maze. 2. At a dose of 1.0 mg/kg, 8-OH-DPAT significantly reduced both efficiency of performance (% correct arm entries) and response rate (arms/min) compared with the saline condition. 3. These effects were completely blocked by WAY-100635 which by itself had no effect on efficiency or response rate. 4. WAY-100635 inhibits 8-OH-DPAT-induced impairment in radial maze performance.

Original language	English
Pages (from-to)	1179-1184
Number of pages	6
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	22
Issue number	7
DOIs	https://doi.org/10.1016/S0278-5846(98)00068-2
State	Published - Oct 1998

Keywords

Learning and memory
Radial maze
Serotonin

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10.1016/S0278-5846(98)00068-2

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title = "Way-100635 reverses 8-OH-DPAT-induced performance impairment in the radial maze",

abstract = "1. The effects of the 5-HT(1A) receptor agonist, (8-OH-DPAT), alone and in combination with the selective 5-HT(1A) antagonist, WAY-100635, were assessed in Fischer-344 rats in an 8-arm radial maze. 2. At a dose of 1.0 mg/kg, 8-OH-DPAT significantly reduced both efficiency of performance (\% correct arm entries) and response rate (arms/min) compared with the saline condition. 3. These effects were completely blocked by WAY-100635 which by itself had no effect on efficiency or response rate. 4. WAY-100635 inhibits 8-OH-DPAT-induced impairment in radial maze performance.",

keywords = "Learning and memory, Radial maze, Serotonin",

author = "Scott Helsley and Siegel, \{Tara L.\} and David Fiorella and Rabin, \{Richard A.\} and Winter, \{J. C.\}",

year = "1998",

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T1 - Way-100635 reverses 8-OH-DPAT-induced performance impairment in the radial maze

AU - Helsley, Scott

AU - Siegel, Tara L.

AU - Fiorella, David

AU - Rabin, Richard A.

AU - Winter, J. C.

PY - 1998/10

Y1 - 1998/10

N2 - 1. The effects of the 5-HT(1A) receptor agonist, (8-OH-DPAT), alone and in combination with the selective 5-HT(1A) antagonist, WAY-100635, were assessed in Fischer-344 rats in an 8-arm radial maze. 2. At a dose of 1.0 mg/kg, 8-OH-DPAT significantly reduced both efficiency of performance (% correct arm entries) and response rate (arms/min) compared with the saline condition. 3. These effects were completely blocked by WAY-100635 which by itself had no effect on efficiency or response rate. 4. WAY-100635 inhibits 8-OH-DPAT-induced impairment in radial maze performance.

AB - 1. The effects of the 5-HT(1A) receptor agonist, (8-OH-DPAT), alone and in combination with the selective 5-HT(1A) antagonist, WAY-100635, were assessed in Fischer-344 rats in an 8-arm radial maze. 2. At a dose of 1.0 mg/kg, 8-OH-DPAT significantly reduced both efficiency of performance (% correct arm entries) and response rate (arms/min) compared with the saline condition. 3. These effects were completely blocked by WAY-100635 which by itself had no effect on efficiency or response rate. 4. WAY-100635 inhibits 8-OH-DPAT-induced impairment in radial maze performance.

KW - Learning and memory

KW - Radial maze

KW - Serotonin

UR - https://www.scopus.com/pages/publications/0032191589

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DO - 10.1016/S0278-5846(98)00068-2

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AN - SCOPUS:0032191589

SN - 0278-5846

VL - 22

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EP - 1184

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

IS - 7

ER -

Way-100635 reverses 8-OH-DPAT-induced performance impairment in the radial maze

Abstract

Keywords

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