TY - JOUR
T1 - Whitepaper
T2 - Defining and investigating cognitive reserve, brain reserve, and brain maintenance
AU - and the Reserve, Resilience and Protective Factors PIA Empirical Definitions and Conceptual Frameworks Workgroup
AU - Stern, Yaakov
AU - Arenaza-Urquijo, Eider M.
AU - Bartrés-Faz, David
AU - Belleville, Sylvie
AU - Cantilon, Marc
AU - Chetelat, Gael
AU - Ewers, Michael
AU - Franzmeier, Nicolai
AU - Kempermann, Gerd
AU - Kremen, William S.
AU - Okonkwo, Ozioma
AU - Scarmeas, Nikolaos
AU - Soldan, Anja
AU - Udeh-Momoh, Chinedu
AU - Valenzuela, Michael
AU - Vemuri, Prashanthi
AU - Vuoksimaa, Eero
AU - Urquiljo, Eider M.Arenaza
AU - Cantillon, Marc
AU - Clouston, Sean A.P.
AU - Estanga, Ainara
AU - Gold, Brian
AU - Habeck, Christian
AU - Jones, Richard
AU - Kochhann, Renata
AU - Lim, Yen Ying
AU - Martínez-Lage, Pablo
AU - Morbelli, Silvia
AU - Okonkwo, Ozioma
AU - Ossenkoppele, Rik
AU - Pettigrew, Corinne
AU - Rosen, Allyson C.
AU - Song, Xiaowei
AU - Van Loenhoud, Anita C.
N1 - Publisher Copyright:
© 2019 the Alzheimer's Association
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Several concepts, which in the aggregate get might be used to account for “resilience” against age- and disease-related changes, have been the subject of much research. These include brain reserve, cognitive reserve, and brain maintenance. However, different investigators have use these terms in different ways, and there has never been an attempt to arrive at consensus on the definition of these concepts. Furthermore, there has been confusion regarding the measurement of these constructs and the appropriate ways to apply them to research. Therefore the reserve, resilience, and protective factors professional interest area, established under the auspices of the Alzheimer's Association, established a whitepaper workgroup to develop consensus definitions for cognitive reserve, brain reserve, and brain maintenance. The workgroup also evaluated measures that have been used to implement these concepts in research settings and developed guidelines for research that explores or utilizes these concepts. The workgroup hopes that this whitepaper will form a reference point for researchers in this area and facilitate research by supplying a common language.
AB - Several concepts, which in the aggregate get might be used to account for “resilience” against age- and disease-related changes, have been the subject of much research. These include brain reserve, cognitive reserve, and brain maintenance. However, different investigators have use these terms in different ways, and there has never been an attempt to arrive at consensus on the definition of these concepts. Furthermore, there has been confusion regarding the measurement of these constructs and the appropriate ways to apply them to research. Therefore the reserve, resilience, and protective factors professional interest area, established under the auspices of the Alzheimer's Association, established a whitepaper workgroup to develop consensus definitions for cognitive reserve, brain reserve, and brain maintenance. The workgroup also evaluated measures that have been used to implement these concepts in research settings and developed guidelines for research that explores or utilizes these concepts. The workgroup hopes that this whitepaper will form a reference point for researchers in this area and facilitate research by supplying a common language.
KW - Alzheimer's disease
KW - Cognition
KW - Epidemiology
KW - Functional imaging
KW - Structural imaging
UR - https://www.scopus.com/pages/publications/85056257256
U2 - 10.1016/j.jalz.2018.07.219
DO - 10.1016/j.jalz.2018.07.219
M3 - Review article
C2 - 30222945
AN - SCOPUS:85056257256
SN - 1552-5260
VL - 16
SP - 1305
EP - 1311
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 9
ER -