Wireless integrated voltametric and amperometric biosensing

Central Nervous System (CNS) uses the interplay between signals of different modalities to transfer and process information. Neurological events are characterized by changes in both neurochemical concentrations and the electrical activity of neurons. Electrophysiological and neurochemical events are highly correlated as one causes the other and vice-versa. The ability to simultaneously record electrical and chemical activity is of considerable research and diagnostic importance. Here, we present a hardware implementation for wireless power and clock transfer to and serial transmission of digitized neurochemical and electrophysiological data from sensors over one RF link. The idea can be extended to sensors of different modalities having widely different data rates. Neurochemical data are acquired in real-time from a custom multichannel very large scale integrated (VLSI) potentiostat chip at 5 Hz. Field potential data were sampled at 400 Hz. A custom VLSI chip powers up and supplies clocks to the potentiostat and telemeters the multiplexed data. All the chips were fabricated in AMI 3M-2P 0.5μ CMOS process. We demonstrate successful operation of the system with wireless powering and telemetry of the multiplexed data.