TY - JOUR
T1 - Yoghurt Intake and Gastric Cancer
T2 - A Pooled Analysis of 16 Studies of the StoP Consortium
AU - Collatuzzo, Giulia
AU - Negri, Eva
AU - Pelucchi, Claudio
AU - Bonzi, Rossella
AU - Turati, Federica
AU - Rabkin, Charles S.
AU - Liao, Linda M.
AU - Sinha, Rashmi
AU - Palli, Domenico
AU - Ferraroni, Monica
AU - López-Carrillo, Lizbeth
AU - Lunet, Nuno
AU - Morais, Samantha
AU - Albanes, Demetrius
AU - Weinstein, Stephanie J.
AU - Parisi, Dominick
AU - Zaridze, David
AU - Maximovitch, Dmitry
AU - Dierssen-Sotos, Trinidad
AU - Jiménez-Moleón, José Juan
AU - Vioque, Jesus
AU - Garcia de la Hera, Manoli
AU - Curado, Maria Paula
AU - Dias-Neto, Emmanuel
AU - Hernández-Ramírez, Raúl Ulises
AU - López-Cervantes, Malaquias
AU - Ward, Mary H.
AU - Tsugane, Shoichiro
AU - Hidaka, Akihisa
AU - Lagiou, Areti
AU - Lagiou, Pagona
AU - Zhang, Zuo Feng
AU - Trichopoulou, Antonia
AU - Karakatsani, Anna
AU - Camargo, Maria Constanza
AU - La Vecchia, Carlo
AU - Boffetta, Paolo
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/4
Y1 - 2023/4
N2 - Background: Yoghurt can modify gastrointestinal disease risk, possibly acting on gut microbiota. Our study aimed at exploring the under-investigated association between yoghurt and gastric cancer (GC). Methods: We pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project. Total yoghurt intake was derived from food frequency questionnaires. We calculated study-specific odds ratios (ORs) of GC and the corresponding 95% confidence intervals (CIs) for increasing categories of yoghurt consumption using univariate and multivariable unconditional logistic regression models. A two-stage analysis, with a meta-analysis of the pooled adjusted data, was conducted. Results: The analysis included 6278 GC cases and 14,181 controls, including 1179 cardia and 3463 non-cardia, 1191 diffuse and 1717 intestinal cases. The overall meta-analysis revealed no association between increasing portions of yoghurt intake (continuous) and GC (OR = 0.98, 95% CI = 0.94–1.02). When restricting to cohort studies, a borderline inverse relationship was found (OR = 0.93, 95% CI = 0.88–0.99). The adjusted and unadjusted OR were 0.92 (95% CI = 0.85–0.99) and 0.78 (95% CI = 0.73–0.84) for any vs. no yoghurt consumption and GC risk. The OR for 1 category of increase in yoghurt intake was 0.96 (95% CI = 0.91–1.02) for cardia, 1.03 (95% CI = 1.00–1.07) for non-cardia, 1.12 (95% CI = 1.07–1.19) for diffuse and 1.02 (95% CI = 0.97–1.06) for intestinal GC. No effect was seen within hospital-based and population-based studies, nor in men or women. Conclusions: We found no association between yoghurt and GC in the main adjusted models, despite sensitivity analyses suggesting a protective effect. Additional studies should further address this association.
AB - Background: Yoghurt can modify gastrointestinal disease risk, possibly acting on gut microbiota. Our study aimed at exploring the under-investigated association between yoghurt and gastric cancer (GC). Methods: We pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project. Total yoghurt intake was derived from food frequency questionnaires. We calculated study-specific odds ratios (ORs) of GC and the corresponding 95% confidence intervals (CIs) for increasing categories of yoghurt consumption using univariate and multivariable unconditional logistic regression models. A two-stage analysis, with a meta-analysis of the pooled adjusted data, was conducted. Results: The analysis included 6278 GC cases and 14,181 controls, including 1179 cardia and 3463 non-cardia, 1191 diffuse and 1717 intestinal cases. The overall meta-analysis revealed no association between increasing portions of yoghurt intake (continuous) and GC (OR = 0.98, 95% CI = 0.94–1.02). When restricting to cohort studies, a borderline inverse relationship was found (OR = 0.93, 95% CI = 0.88–0.99). The adjusted and unadjusted OR were 0.92 (95% CI = 0.85–0.99) and 0.78 (95% CI = 0.73–0.84) for any vs. no yoghurt consumption and GC risk. The OR for 1 category of increase in yoghurt intake was 0.96 (95% CI = 0.91–1.02) for cardia, 1.03 (95% CI = 1.00–1.07) for non-cardia, 1.12 (95% CI = 1.07–1.19) for diffuse and 1.02 (95% CI = 0.97–1.06) for intestinal GC. No effect was seen within hospital-based and population-based studies, nor in men or women. Conclusions: We found no association between yoghurt and GC in the main adjusted models, despite sensitivity analyses suggesting a protective effect. Additional studies should further address this association.
KW - diet
KW - gastric cancer
KW - nutrition
KW - yoghurt
UR - https://www.scopus.com/pages/publications/85156106339
U2 - 10.3390/nu15081877
DO - 10.3390/nu15081877
M3 - Article
AN - SCOPUS:85156106339
SN - 2072-6643
VL - 15
JO - Nutrients
JF - Nutrients
IS - 8
M1 - 1877
ER -